Patents Assigned to Protaffin Biotechnologie AG
  • Glycosaminoglycan-antagonising MCP-1 mutants
    Patent number: 8337825
    Abstract: Novel mutants of human monocyte chemoattractant protein 1 (MCP-1) with increased glycosaminoglycan (GAG) binding affinity and knocked-out or reduced GPCR activity compared to wild type MCP-1, and their use for therapeutic treatment of inflammatory diseases.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: December 25, 2012
    Assignee: Protaffin Biotechnologie AG
    Inventors: Andreas Kungl, Anna Maria Piccinini, Christian Weber
  • USE OF MODIFIED INTERLEUKIN-8 PROTEINS FOR TREATING REPERFUSION INJURY OR TRANSPLANT REJECTION
    Publication number: 20110229433
    Abstract: The present invention relates to the use of a modified interleukin 8 (IL-8) having increased GAG binding affinity and further inhibited or down-regulated biological activity compared to the respective wild type IL-8 for preparing a medicament for the prevention and/or treatment of ischemia reperfusion injury and/or transplant rejection in patients.
    Type: Application
    Filed: August 28, 2007
    Publication date: September 22, 2011
    Applicant: Protaffin Biotechnologie AG
    Inventors: Andreas J. Kungl, Jens Bedke, Hermann-Josef Gröne
  • GAG binding protein
    Patent number: 7807413
    Abstract: A method is provided for introducing a GAG binding site into a protein comprising the steps: identifying a region in a protein which is not essential for structure maintenance introducing at least one basic amino acid into said site and/or deleting at least one bulky and/or acidic amino acid in said site, whereby said GAG binding site has a GAG binding affinity of Kd?10 ?M, preferably ?1 ?M, still preferred ?0.1 ?M, as well as modified GAG binding proteins.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: October 5, 2010
    Assignee: Protaffin Biotechnologie AG
    Inventor: Andreas J. Kungl
  • SYSTEM TO ASSESS THE BIOLOGICAL ACTIVITY OF CHEMOATTRACTANTS
    Publication number: 20100035294
    Abstract: The present invention relates to a system for measuring the biological activity of chemoattractants comprising at least two units separated by a semipermeable carrier wherein biologically active carbohydrate structures, preferably glycosaminoglycan (GAG) structures, are immobilized on the surface of said carrier. According to the invention, this system can be used for fast and economic measurement of the degree of cell mobility and chemotactic activity.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 11, 2010
    Applicant: Protaffin Biotechnologie AG
    Inventor: Andreas J. Kungl
  • GAG binding proteins
    Patent number: 7585937
    Abstract: A method is provided for introducing a GAG binding site into a protein comprising the steps: identifying a region in a protein which is not essential for structure maintenance introducing at least one basic amino acid into said site and/or deleting at least one bulky and/or acidic amino acid in said site, whereby said GAG binding site has a GAG binding affinity of Kd?10 ?M, preferably 1 ?M, still preferred ?0.1 ?M, as well as modified GAG binding proteins.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: September 8, 2009
    Assignee: Protaffin Biotechnologie AG
    Inventor: Andreas J. Kungl