Patents Assigned to Protalix Ltd.
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Patent number: 8119406Abstract: A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.Type: GrantFiled: October 11, 2005Date of Patent: February 21, 2012Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Sharon Hashmueli, Daniel Bartfeld, Gideon Baum, Tal Ratz, Einat Mizrachi, Yehava Forester
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Publication number: 20110250181Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 6, 2011Publication date: October 13, 2011Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110182868Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 6, 2011Publication date: July 28, 2011Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110159590Abstract: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which may be used for large-scale production of cells and tissues. According to preferred embodiments of the present invention, the present invention is adapted for use with plant cell culture.Type: ApplicationFiled: January 18, 2011Publication date: June 30, 2011Applicant: Protalix Ltd.Inventor: Yoseph SHAALTIEL
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Patent number: 7951557Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 30, 2007Date of Patent: May 31, 2011Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110105379Abstract: Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.Type: ApplicationFiled: August 20, 2008Publication date: May 5, 2011Applicant: Protalix Ltd.Inventors: Avidor Shulman, Ilya Ruderfer
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Publication number: 20110070201Abstract: A method of systemically delivering a biologically active, recombinant biomolecule, in a biologically active form, to a subject in need thereof. , the method comprising, enterally or mucosally administering to the subject a therapeutically effective amount of plant cells expressing an exogenous biologically active recombinant biomolecule, thereby systemically delivering the biologically active recombinant biomolecule, in a biologically active form, to the subject.Type: ApplicationFiled: July 18, 2006Publication date: March 24, 2011Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Einat Almon
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Publication number: 20100136673Abstract: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which may be used for large-scale production of cells and tissues. According to preferred embodiments of the present invention, the present invention is adapted for use with plant cell culture.Type: ApplicationFiled: January 21, 2010Publication date: June 3, 2010Applicant: Protalix Ltd.Inventor: Yoseph SHAALTIEL
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Publication number: 20100112700Abstract: A reusable, disposable device for culturing plant tissues or cells including a non-rigid container having dimensions and gas exchange ports designed for maintaining oxygen saturation and shear forces suitable for culturing plant tissue or cells in 400 liters or more of culture medium is provided. Also provided are methods for producing a catalytically active human recombinant protein in a plant cell, using the disposable device of one of the embodiments of the instant specification.Type: ApplicationFiled: May 5, 2008Publication date: May 6, 2010Applicant: PROTALIX LTD.Inventors: Yoseph Shaaltiel, Yair Kirshner, Alon Shtainiz, Yaron Naos, Yftach Shneor
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Patent number: 7655781Abstract: The present invention provides human glycoprotein hormone (hGPH) ?-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.Type: GrantFiled: May 5, 2006Date of Patent: February 2, 2010Assignees: Compugen Ltd., Protalix Ltd.Inventors: Ronen Shemesh, Jeanne Bernstein, Dvir Dahary, Gil Shalev, Gideon Baum, Yoseph Shaaltiel
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Publication number: 20090208477Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 23, 2009Publication date: August 20, 2009Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20090082548Abstract: A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.Type: ApplicationFiled: October 11, 2005Publication date: March 26, 2009Applicant: PROTALIX LTD.Inventors: Yoseph Shaaltiel, Sharon Hashmueli, Daniel Bartfeld, Gideon Baum, Tal Ratz, Einat Mizrachi, Yehava Forester
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Publication number: 20090053762Abstract: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which may be used for large-scale production of cells and tissues. According to preferred embodiments of the present invention, the present invention is adapted for use with plant cell culture.Type: ApplicationFiled: November 8, 2007Publication date: February 26, 2009Applicant: Protalix Ltd.Inventor: Yoseph Shaaltiel
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Publication number: 20080038232Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 30, 2007Publication date: February 14, 2008Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20060204487Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: February 24, 2004Publication date: September 14, 2006Applicant: PROTALIX LTD.Inventors: Yoseph Shaaltiel, Gideon Baum, Sharon Hashmueli, Ayala Lewkowicz, Daniel Bartfeld