Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

Abstract: The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.

Abstract: The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating misfolded protein diseases comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating selective autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

Abstract: The present invention provides a compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof which can be effectively used for preventing or treating obesity or metabolic syndrome, and a pharmaceutical composition comprising the same. in Chemical Formula 1, R1 and R2 are the same as defined in the specification.

Abstract: A toe-tapping exercise machine includes: a foot rest part having a right foot rest adapted to seat a user's right foot thereon and a left foot rest adapted to seat the user's left foot thereon; and an operating part coupled to the foot rest part to allow toe portions of the foot rest part to tap each other, the operating part including: a driving motor for transferring rotating power; a right foot rest operator for receiving the rotating power from the driving motor to operate the right foot rest; and a left foot rest operator for receiving the rotating power from the driving motor to operate the left foot rest, the driving motor being disposed between the right foot rest operator and the left foot rest operator and having rotary shafts extended from both sides thereof.

Abstract: A toe-tapping exercise machine comprises: a foot rest part having a right foot rest adapted to seat a user's right foot thereon and a left foot rest adapted to seat the user's left foot thereon; and an operating part coupled to the foot rest part to allow toe portions of the foot rest part to tap each other, the operating part comprising: a driving motor for transferring rotating power; a right foot rest operator for receiving the rotating power from the driving motor to operate the right foot rest; and a left foot rest operator for receiving the rotating power from the driving motor to operate the left foot rest, the driving motor being disposed between the right foot rest operator and the left foot rest operator and having rotary shafts extended from both sides thereof.

Abstract: There is provided a meal-serving stock shelf-equipped wheelchair, with which the wheelchair user can efficiently perform meal-serving work when charged with the work, and in which the stock shelf is capable of being folded in a compact manner after the meal serving. The meal-serving motorized wheelchair includes: a wheelchair meal-serving table that is attached via a frame; and a meal-serving stock shelf that is engaged with an engaging plate via an engaging portion. The meal-serving stock shelf is structured by a raising and lowering mechanism powered by a motor and a dish tray storage section. The dish tray storage section stores dish trays of at least two levels disposed at a predetermined interval. The stock shelf can be folded in a compact manner when not in use.

Abstract: Disclosed herein is a heel protector including a body member made of a flexible fabric material for being worn on the feet and an inner pad member coupled to an inside of the body member for accommodation to an area where a heel is located when the heel protector is worn. Both distal ends of a longitudinal direction of the inner pad member are coupled to the body member, and two areas of the inner pad member accommodated to both lateral sections of the heel are coupled to the body member, such that the inner pad member can relatively slide in relation to the body member when the heel protector is worn. Friction generated on the heels while walking can be subdued by the inner pad member to thereby prevent formation of calluses or blisters, and manufacturing process can be simplified to reduce the manufacturing cost.