Abstract: A highly specific and sensitive technique for exploring cell physiology is disclosed. The method includes laser capture microdissection (LCM) for selecting small clusters of cells of interest from sections of tissue and matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) for characterizing simultaneously a broad variety of biological molecules present in the small cluster of cells.
Type:
Grant
Filed:
October 6, 2000
Date of Patent:
March 11, 2003
Assignees:
The General Hospital Corporation, ProteiGene, Inc.
Inventors:
Darryl E. Palmer-Toy, David Sarracino, Dennis Sgroi, Peter Leopold