Abstract: Bioengineered scaffolds are described, using human skin proteins in an architectural orientation that mimics the extracellular matrix, demonstrating improved cutaneous wound closure in vivo alone, and when incorporating therapeutics such as platelet-rich plasma, stem cells, and growth factors that promote accelerated wound healing compared to control therapy. An electrospun scaffold comprising human collagen I and tropoelastin in physiologically relevant amounts and proportions encourage a chronic wound that is halted in the inflammatory phase to progress into the remodeling phase. Data demonstrates full thickness, splinted wounds in diabetic mice were treated with biomimetic scaffolds to assess wound healing and the resulting remodeled tissue mechanical properties.

Abstract: The present invention relates to biocompatible polymeric scaffold materials, methods for making the materials and methods of using the materials. More particularly, the present invention relates to implants and grafts comprising polymeric scaffold materials of cross-linked human tropoelastin polypeptides and methods of making and using the same. In addition, the present invention provides alternatively spliced tropoelastin polynucleotides and polypeptides.

Abstract: The present invention relates to biocompatible polymeric scaffold materials, methods for making the materials and methods of using the materials. More particularly, the present invention relates to implants and grafts comprising polymeric scaffold materials of cross-linked human tropoelastin polypeptides and methods of making and using the same. In addition, the present invention provides alternatively spliced tropoelastin polynucleotides and polypeptides.