Patents Assigned to Protein Technologies, Inc.
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Patent number: 11964237Abstract: A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a relatively high concentration of desired molecule, due to a relatively small volume.Type: GrantFiled: March 11, 2022Date of Patent: April 23, 2024Assignee: Integrated Protein Technologies, Inc.Inventors: Philip D. Compton, Jared Drader
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Patent number: 11850556Abstract: A frit comprising a plurality of grooves; a drain hole; a transverse crossing lane; wherein said plurality of grooves are substantially parallel to one another and extend longitudinally across said frit; wherein said plurality of grooves comprise at least two different lengths; wherein said transverse crossing lane is substantially perpendicular to said plurality of grooves; wherein said drain hole is located within said transverse crossing lane; wherein said drain hole is located at a center of said transverse crossing lane.Type: GrantFiled: November 12, 2020Date of Patent: December 26, 2023Assignee: Integrated Protein Technologies, Inc.Inventors: Philip D. Compton, Jared Drader
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Publication number: 20190389958Abstract: The present invention relates to monospecific antibodies against CXCR4 or binding fragments thereof, to the use of such anti-CXCR4 antibodies or binding fragments in treating diseases whose pathogenesis is related to activation of CXCR4, as well as to pharmaceutical compositions comprising such anti-CXCR4 antibodies or binding fragments.Type: ApplicationFiled: January 31, 2017Publication date: December 26, 2019Applicant: MSM Protein Technologies, Inc.Inventors: Andres McAllister, Corinne Moulton, Colleen Stauffer-Kelleher, Svetlana Abbasova, Viktoriia Vasilyeva, Olga Rimkevich, Andrey Ulitin, Roman Mikhaylov, Tajib Mirzabekov, David Kreimer, Eldar Kim
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Publication number: 20140206841Abstract: Apparatus and methods utilizing infrared energy for heating reactions associated with peptide synthesis, such as activation, deprotection, coupling, and cleavage. Thorough agitation of the contents of reaction vessels during heating and real-time monitoring and adjustment of temperature and/or reaction duration are also described. Existing peptide synthesizers may be retrofitted to include an infrared energy source.Type: ApplicationFiled: January 18, 2013Publication date: July 24, 2014Applicant: Protein Technologies, Inc.Inventors: Mahendra Menakuru, Alexander Waddell
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Patent number: 8535947Abstract: A method for on-line monitoring of deprotection reaction in a peptide automated synthesizer comprising UV detector is disclosed. A UV source, detector, electronics, and housing are integrated with a line or tube through which liquid reactants flow for periodic measurements in the peptide synthesizer. The method includes determining the progression of the reaction, completion point of the reaction, and the modification of the reaction times and repetitions in real time.Type: GrantFiled: September 30, 2010Date of Patent: September 17, 2013Assignee: Protein Technologies, Inc.Inventors: Mahendra S. Menakuru, Robert William Hensley, Joseph B. E. Blais
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Publication number: 20120080608Abstract: Methods, devices and systems for on-line UV monitoring of automated synthesizer reactions. The device includes a UV source, detector, electronics, and housing that are integrated with a line or tube through which liquid reactants flow for periodic measurements in a synthesizer system. The methods include the measurements and methods for determining the progression of the reaction, completion point of the reaction, and the modification of the reaction times and repetitions in real time.Type: ApplicationFiled: September 30, 2010Publication date: April 5, 2012Applicant: Protein Technologies, Inc.Inventors: Mahendra S. Menakuru, Robert William Hensley, Joseph B.E. Blais
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Patent number: 7678335Abstract: This invention relates to an apparatus for simultaneously carrying out multiple and highly parallel synthesis of compounds based on the solid-phase synthesis technique, in particular, peptide synthesis. Time-consuming and costly multiple rinsing processes required in solid-phase synthesis after distributing and replacing the reagents can be avoided by proposing an improved apparatus for fully automatic synthesis and subsequent separation of the synthesized compounds that involves separate synthesizer pins 11 for each synthetic unit with a reagent reservoir 20; 21 and individual dosing capability. These synthesizer pins 11 are provided in a separate holder 4 from where they are picked up by the gripper arm 2 of the automatic synthesizer 1. The openings of the reaction chambers 9 of the synthesizer plates 5 are closed (covered) by a permeable material 25 for contamination-free placement of the synthesizer pins 11 and adding reagent doses to the solid or liquid phases.Type: GrantFiled: April 25, 2002Date of Patent: March 16, 2010Assignee: Protein Technologies, Inc.Inventors: Oliver Johannes Kreuzer, Carsten Hessenius, Carsten Grotzinger, Volker Johannson, Ralph-Th. Roeder
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Patent number: 7473764Abstract: A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a protein rich solution substantially free of myofibrils and sarcomere tissue structure. The protein rich aqueous solution can be treated to effect protein precipitation, followed by protein recovery.Type: GrantFiled: August 9, 2007Date of Patent: January 6, 2009Assignee: Advanced Protein Technologies, IncInventors: Herbert O. Hultin, Stephen D. Kelleher
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Patent number: 6451975Abstract: A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a protein rich solution substantially free of myofibrils and sarcomere tissue structure. The protein rich aqueous solution can be treated to effect protein precipitation, followed by protein recovery.Type: GrantFiled: August 29, 1997Date of Patent: September 17, 2002Assignee: Advanced Protein Technologies, Inc.Inventors: Herbert O. Hultin, Stephen D. Kelleher
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Patent number: 6288216Abstract: A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a protein rich solution. A protein rich aqueous solution is separated from solids and lipids, including membrane lipids. The protein rich aqueous solution can be treated to effect protein precipitation, followed by protein recovery.Type: GrantFiled: January 29, 1998Date of Patent: September 11, 2001Assignee: Advanced Protein Technology, Inc.Inventors: Herbert O. Hultin, Stephen D. Kelleher
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Patent number: 6005073Abstract: A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a protein rich solution. A protein rich aqueous solution is separated from solids and lipids, including membrane lipids. The protein rich aqueous solution can be treated to effect protein precipitation, followed by protein recovery.Type: GrantFiled: February 12, 1997Date of Patent: December 21, 1999Assignee: Advanced Protein Technologies, Inc.Inventors: Herbert O. Hultin, Stephen D. Kelleher
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Patent number: 5980839Abstract: The objective of combinatorial chemical synthesis is the preparation of a very large number of different molecular entities by a randomized process of sequential chemical syntheses. The present invention provides a combinatorial vessel comprising a reaction region and a mixing region, adjacent to each other, which can be used to practice combinatorial chemical synthesis. The reaction region comprises a plurality of reaction cavities, in which a plurality of different chemical reactions may be performed simultaneously on resin beads. The resin beads are then transferred to the mixing region and mixed into a single group. Then, the resin beads are transferred into the reaction cavities. The process of performing reactions, transferring to the mixing region, mixing, and transferring to the reaction region can be repeated multiple times to obtain a large number of resin beads, each of which has been exposed to a series of reactions different from most of the other resin beads.Type: GrantFiled: February 11, 1998Date of Patent: November 9, 1999Assignee: Protein Technologies, Inc.Inventors: Milan Bier, German Eduardo Fuentes, Rodolfo Bacheleir Marquez, Anthony Ralph Ford
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Patent number: 5540826Abstract: A multi-channel separation device is provided for use in separation technology, particularly in electrophoresis and in isoelectric focusing. The device includes two mating plates, at least one of which contains an array of at least three cavities arranged to define a serpentine fluid pathway through the cavities when the plates are mated. Each of the cavities includes fluid input and output ports to facilitate transfer of process fluid through the cavities. A septum is disposed between the plates for streamlining fluid flow between the input and output ports by restricting but not preventing free fluid flow between adjacent cavities. The device also includes anodic and cathodic compartments containing electrodes for establishing an electric field across the cavities.Type: GrantFiled: March 15, 1995Date of Patent: July 30, 1996Assignee: Protein Technologies, Inc.Inventors: Milan Bier, Terry D. Long, Rodolfo Marquez, Anthony R. Ford
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Patent number: 5447612Abstract: A novel pH buffering system which is functionally stable under electrophoretic conditions employs buffering components in complementary buffer pairs. The buffering components are selected from among simple chemically defined ampholytes, weak acids and weak bases, and are paired together on the basis of their dissociation characteristics to define narrow overlapping buffering zones in which the buffering components exhibit low net electrophoretic mobility combined with desired pH buffering capacity. The narrow buffering zones cover from 0.4 to 1.25 pH units within a broad range of pH values of from about pH 3 to about pH 10. Specific buffering pH values within the narrow buffering zones are obtainable by varying the molar ratios of the two buffering components of the selected buffer pair. The buffering system may be used to form functionally stable precast narrow pH zone gradients in free solution, and has particular utility in isoelectric focusing and other electrophoretic processes.Type: GrantFiled: December 22, 1994Date of Patent: September 5, 1995Assignee: Protein Technologies, Inc.Inventors: Milan Bier, Terry D. Long, Rodolfo B. Marguez, James A. Ostrem
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Patent number: 5241048Abstract: Chemical reactions are readily carried out using supercritical carbon dioxide as the reaction medium. Supercritical carbon dioxide is of special value as a reaction medium in reactions for synthesizing polypeptides, for sequencing polypeptides, or for amino acid analysis.Type: GrantFiled: November 6, 1990Date of Patent: August 31, 1993Assignee: Protein Technologies, Inc.Inventors: Leon E. Barstow, Glen D. Ward, Milan Bier
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Patent number: 5203368Abstract: A matrix of valves being formed using a sandwich of three layers with a pliable membrane interposed between two of the layers. Supply channels and delivery channels are created through etching, routing, or other such means on the middle layer. Each supply channel communicates with all of the delivery channels via a valve location which is opened or closed by pneumatic pressure on the pliable membrane. Movement of the pliable membrane is affected through suction or pressure as communicated via holes in the overlying layer. In this manner, selected supply and delivery lines are connected by appropriate suction being placed on the membrane. Selected valves are simultaneously opened to provide parallel operations.Type: GrantFiled: July 29, 1992Date of Patent: April 20, 1993Assignee: Protein Technologies Inc.Inventors: Leon E. Barstow, Anthony R. Ford, Terry D. Long, Glen D. Ward
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Patent number: 5198213Abstract: Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.Type: GrantFiled: October 16, 1991Date of Patent: March 30, 1993Assignee: Protein Technology, Inc.Inventors: Gerald H. Stott, David O. Lucas
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Patent number: 5066491Abstract: Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.Type: GrantFiled: February 3, 1989Date of Patent: November 19, 1991Assignee: Protein Technology, Inc.Inventors: Gerald H. Stott, David O. Lucas
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Patent number: 5064940Abstract: A novel and convenient process is described for providing protected amino acids and activating agents for solid phase synthesis which drastically reduces the capital costs of equipment required for the preparation of peptides. The two normally very reactive reagents, when mixed as anhydrous powders are shelf stable and yet form an active compound rapidly when mixed together in solution. This invention presents a method for combining these highly reactive dry solids in a manner which makes them unreactive and shelf stable at room temperature for extended periods of time. Once the solids are dissolved in solvent, a highly reactive amino acid ester that can readily be used in solid phase peptide synthesis is formed. This method of delivery of reagents to an automated peptide synthesizer allowers a very simplified instrument to be constructed using fewer and less expensive components and significantly reducing the associated software required.Type: GrantFiled: September 14, 1990Date of Patent: November 12, 1991Assignee: Protein Technologies, Inc.Inventors: Leon E. Barstow, Glen D. Ward
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Patent number: 5001224Abstract: Chemical reactions are readily carried out using supercritical carbon dioxide as the reaction medium. Supercritical carbon dioxide is of special value as a reaction medium in reactions for synthesizing polypeptides, for sequencing polypeptides, or for amino acid analysis.Type: GrantFiled: March 11, 1988Date of Patent: March 19, 1991Assignee: Protein Technologies, Inc.Inventors: Leon E. Barstow, Glen D. Ward, Milan Bier