Patents Assigned to Protein Technologies International, Inc.
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Publication number: 20010029248Abstract: The present invention is a composition comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. The present invention is also a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.Type: ApplicationFiled: March 30, 2001Publication date: October 11, 2001Applicant: Protein Technologies International, Inc.Inventors: Doyle H. Waggle, Susan M. Potter, E. C. Henley
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Patent number: 6300367Abstract: The present invention is a composition for preventing, minimizing, or reversing the development or growth of breast cancer. The composition contains a combination of a selective estrogen receptor modulator selected from at least one of raloxifene, droloxifene, toremifene, 4′-iodotamoxifen, and idoxifene and at least one isoflavone selected from genistein, daidzein, biochanin A, formononetin, and their respective naturally occurring glucosides and glucoside conjugates. The present invention also provides a method of preventing, minimizng, or reversing the development or growth of breast cancer in which a selective estrogen receptor modulator selected from at least one of raloxifene, droloxifene, toremifene, 4′-iodotamoxifen, and idoxifene is co-administered with at least one isoflavone selected from genistein, daidzein, biochanin A, formononetin, and their naturally occuring glucosides and glucoside conjugates to a woman having or predisposed to having breast cancer.Type: GrantFiled: April 20, 1999Date of Patent: October 9, 2001Assignee: Protein Technologies International, Inc.Inventors: Richard B. Taylor, E. C. Henley
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Publication number: 20010026814Abstract: The present invention is a composition comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. The present invention is also a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.Type: ApplicationFiled: March 22, 2001Publication date: October 4, 2001Applicant: Protein Technologies International, Inc.Inventors: Doyle H. Waggle, Susan M. Potter, Edna C. Henley
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Publication number: 20010024666Abstract: The present invention is a composition comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. The present invention is also a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.Type: ApplicationFiled: April 4, 2001Publication date: September 27, 2001Applicant: Protein Technologies International, Inc.Inventors: Doyle H. Waggle, Susan M. Potter, Edna C. Henley
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Publication number: 20010018197Abstract: A method is provided for purifying a vegetable protein material by removing ribonucleic acids, phytic acid, and phytates from the protein material. An aqueous slurry is formed of a vegetable protein material having a pH of from about 3 to about 6. The protein material slurry is treated with an acid phosphatase enzyme, and optionally another phytase enzyme, at a temperature and for a time effective to degrade ribonucleic acids, and optionally phytic acid and phytates, in the protein material. The enzyme treated slurry is then washed to remove the degraded materials.Type: ApplicationFiled: February 16, 2001Publication date: August 30, 2001Applicant: Protein Technologies International, Inc.Inventors: Theodore M. Wong, David A. Singer, Santa H. Lin, Terry T. Lin
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Patent number: 6187367Abstract: A low viscosity, high gel strength protein-starch composition is provided. The protein-starch composition contains a denatured protein material and a starch material which are complexed together where the starch material is in a substantially non-gelatinized state. The protein-starch composition has a low viscosity prior to cooking, yet has a high gel strength after being cooked. A meat emulsion is also provided which contains a meat material and the protein-starch composition. A process is provided for forming the protein-starch composition in which an aqueous slurry of a protein material is formed, the protein in the slurry is denatured by subjecting the slurry to temperatures sufficient to denature the protein, a starch material is mixed into the slurry of denatured protein, and the slurry of starch and protein material is spray dried under conditions which cause the protein material and starch material to complex without gelatinizing the starch material.Type: GrantFiled: September 25, 1997Date of Patent: February 13, 2001Assignee: Protein Technologies International, Inc.Inventors: Iue Chung Cho, Charles Edward Coco, Gregory A. Bates
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Protein isolate having an increased level of isoflavone compounds and process for producing the same
Patent number: 6140469Abstract: The present invention relates to the production of an isoflavone enriched vegetable protein isolate in which the weight ratio of material to extractant is controlled and washing of the acid precipitated protein curd is avoided or minimized to provide an increased level of isoflavones in the protein isolate.Type: GrantFiled: October 12, 1993Date of Patent: October 31, 2000Assignee: Protein Technologies International, Inc.Inventors: Jerome L Shen, Balagtas Francisco Guevara, Frank Enrico Spadafora -
Patent number: 6132795Abstract: The present invention is a vegetable protein composition. The vegetable protein composition contains an isoflavone depleted vegetable protein material and an isoflavone containing material which is dispersed in the isoflavone depleted vegetable protein material. The composition may be used in foods to provide the nutritional benefits of the isoflavone depleted vegetable protein material while providing the health benefits of the isoflavone containing material. The invention also includes processes for forming such vegetable protein compositions.Type: GrantFiled: March 15, 1998Date of Patent: October 17, 2000Assignee: Protein Technologies International, Inc.Inventors: James L. Holbrook, Doyle H. Waggle
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Patent number: 6083553Abstract: Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered from soy molasses. In a second embodiment, a method is disclosed whereby isoflavone conjugates present in soy molasses are converted to isoflavone glucosides, and an isoflavone glucoside material is recovered from the soy molasses. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form, and an aglucone isoflavone material is recovered from soy molasses.Type: GrantFiled: June 5, 1998Date of Patent: July 4, 2000Assignee: Protein Technologies International, Inc.Inventors: Doyle H. Waggle, Barbara A. Bryan
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Patent number: 6015785Abstract: Aglucone isoflavone enriched vegetable protein extract and isolate and process for producing and recovering are disclosed. The aglucone isoflavone extract is made by extracting a vegetable protein material comprising glucone isoflavones with an aqueous extractant having a pH above about the isoelectric point of the protein material to produce an aqueous extract, and reacting the glucone isoflavones with a sufficient amount of beta-glucosidase enzyme or esterase enzyme for a time period, temperature, and pH sufficient to convert at least a majority of the glucone isoflavones in the extract to aglucone isoflavones and thereby produce the aglucone isoflavone enriched extract. The aglucone isoflavone enriched isolates are produced by adjusting the pH of the reacted extract to about the isoelectric point of the vegetable protein material to precipitate the protein material, and separating the protein material to produce an aglucone enriched protein isolate.Type: GrantFiled: October 31, 1997Date of Patent: January 18, 2000Assignee: Protein Technologies International, Inc.Inventors: Jerome L. Shen, Barbara A. Bryan
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Patent number: 6013771Abstract: A process for providing an isoflavone rich protein isolate is provided, along with the isoflavone rich protein isolate produced thereby. A vegetable material containing protein and at least one isoflavone compound is extracted with an aqueous extractant having a pH above the isoelectric point of the protein, and preferably an alkaline pH. The protein and isoflavones are extracted into the extractant, and the extractant containing the protein and isoflavones is separated from insoluble vegetable protein materials to form a protein extract. The pH of the protein extract is adjusted to about the isoelectric point of the protein to precipitate the protein. The extract containing the precipitated protein is cooled to a temperature of about 40.degree. F. to about 80.degree. F., and then the protein is separated from the extract. Washing of the separated protein is avoided, or, is conducted with minimum amounts of water.Type: GrantFiled: June 9, 1998Date of Patent: January 11, 2000Assignee: Protein Technologies International, Inc.Inventors: Jerome L. Shen, Balagtas F. Guevara, Frank E. Spadafora, Barbara A. Bryan
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Patent number: 6001368Abstract: A method is provided for inhibiting or reducing the risk of macular degeneration with phytoestrogenic isoflavones. A further method is provided for inhibiting or reducing the risk of macular degeneration with a soy protein material containing phytoestrogenic isoflavones.Type: GrantFiled: September 3, 1998Date of Patent: December 14, 1999Assignee: Protein Technologies International, Inc.Inventor: Belinda H. Jenks
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Patent number: 5994508Abstract: A process for providing an isoflavone rich protein isolate is provided, along with the isoflavone rich protein isolate produced thereby. A vegetable material containing protein and at least one isoflavone compound is extracted with an aqueous extractant having a neutral pH. The protein and isoflavones are extracted into the extractant, and the extractant containing the protein and isoflavones is separated from insoluble vegetable materials to form a protein extract. The pH of the protein extract is adjusted to about the isoelectric point of the protein to precipitate the protein. The extract containing the precipitated protein is cooled to a temperature of from about 40.degree. F. to about 80.degree. F., and then the protein is separated from the extract. The cool separation temperatures unexpectedly significantly increase the concentration of isoflavones recovered in the separated protein, while the neutral extract pH inhibits loss of protein normally observed at cool or cold separation temperatures.Type: GrantFiled: April 13, 1998Date of Patent: November 30, 1999Assignee: Protein Technologies International, Inc.Inventors: Barbara A. Bryan, Balagtas F. Guevara
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Patent number: 5990291Abstract: Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.Type: GrantFiled: December 3, 1998Date of Patent: November 23, 1999Assignee: Protein Technologies International, Inc.Inventors: Doyle H. Waggle, Barbara A. Bryan
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Patent number: 5952374Abstract: Methods for inhibiting the development and relieving the symptoms of Alzheimer's disease and related dementias are provided. A phytoestrogenic isoflavone compound is administered to a human predisposed to developing Alzheimer's disease or a related dementia, or having Alzheimer's disease or a related dementia, in an amount effective to inhibit the development or relieve the symptoms of the disease. The phytoestrogenic isoflavone compound is selected from at least one of genistein, genistin, 6'-OMal genistin, 6'-OAc genistin, daidzein, daidzin, 6'-OMal daidzin, 6'-OAc daidzin, glycitein, glycitin, 6'-OMal glycitin, or mixtures thereof. The phytoestrogenic isoflavone compound is effective to up-regulate choline acetyltransferase mRNA and nerve growth factor mRNA.Type: GrantFiled: September 29, 1997Date of Patent: September 14, 1999Assignee: Protein Technologies International, Inc.Inventors: Thomas Boston Clarkson, Jr., Mary Susan Anthony, Yuanlong Pan, Michael R. Adams, Doyle H. Waggle
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Patent number: 5919921Abstract: Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.Type: GrantFiled: May 29, 1998Date of Patent: July 6, 1999Assignee: Protein Technologies International, Inc.Inventors: Doyle H. Waggle, Barbara A. Bryan
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Patent number: 5827682Abstract: Disclosed are methods for converting isoflavone conjugates in vegetable protein materials to isoflavone aglucones by forming an aqueous mixture of a vegetable protein material containing isoflavone conjugates, converting the isoflavone conjugates to isoflavone glucones, and converting the isoflavone glucones to isoflavone aglucones. The vegetable protein material may also contain isoflavone glucones which are converted to isoflavone aglucones. The isoflavone conjugates, isoflavone glucones, or isoflavone aglucones present in the vegetable protein material may be removed from the vegetable materials before, during, or after the conversion process.Type: GrantFiled: October 15, 1996Date of Patent: October 27, 1998Assignee: Protein Technologies International, Inc.Inventors: Barbara A. Bryan, Maryann C. Allred, Mark A. Roussey
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Patent number: 5821361Abstract: Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.Type: GrantFiled: June 11, 1996Date of Patent: October 13, 1998Assignee: Protein Technologies International, Inc.Inventors: Doyle Waggle, Barbara Bryan
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Patent number: 5766331Abstract: A paper coating composition comprising a paper coating pigment and a protein adhesive. The protein adhesive contains a protein material and a dispersing agent, in an amount effective to adjust the pH of an aqueous solution containing the paper coating composition sufficiently to substantially solubilize the protein material, comprising a basic reagent containing a divalent cation and a cation binding agent. The cation binding agent is present in an amount effective to inhibit divalent cation induced gel formation and pigment flocculation.Type: GrantFiled: October 25, 1996Date of Patent: June 16, 1998Assignee: Protein Technologies International, Inc.Inventors: Thomas L. Krinski, Lawrence M. Scacciaferro
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Patent number: 5763389Abstract: Aglucone isoflavone enriched vegetable protein extract and isolate and processes for producing and recovering are disclosed. The aglucone isoflavone extract is made by extracting a vegetable protein material comprising glucone isoflavones with an aqueous extractant having a pH above about the isoelectric point of the protein material to produce an aqueous extract, and reacting the glucone isoflavones with a sufficient amount of beta-glucosidase enzyme or esterase enzyme for a time period, temperature, and pH sufficient to convert at least a majority of the glucone isoflavones in the extract to aglucone isoflavones and thereby produce the aglucone isoflavone enriched extract. The aglucone isoflavone enriched isolates are produced by adjusting the pH of the reacted extract to about the isoelectric point of the vegetable protein material to precipitate the protein material, and separating the protein material to produce an aglucone enriched protein isolate.Type: GrantFiled: April 12, 1996Date of Patent: June 9, 1998Assignee: Protein Technologies International, Inc.Inventors: Jerome L. Shen, Barbara A. Bryan