Patents Assigned to Protelica, Inc.
  • Fibronectin binding domain chimeric antigen receptors and methods of use thereof
    Patent number: 12331103
    Abstract: Provided herein are chimeric antigen receptors (CARs) for binding with a target antigen, comprising at least one antigen specific targeting region comprising a fibronectin type 3 (FN3) domain polypeptide. Provided herein are multispecific chimeric antigen receptors for binding with two or more target antigens, comprising at least two antigen specific targeting regions comprising a fibronectin type 3 domain polypeptide. Also provided herein are compositions and methods of treatment relating to the use of subject CARs of the invention.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: June 17, 2025
    Assignee: PROTELICA, INC.
    Inventors: Roberto Crea, Jun Yoon, Craig A. Hokanson, Emanuela Zacco
  • Universal fibronectin type III binding-domain libraries
    Patent number: 9376483
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: June 28, 2016
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20140135474
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 15, 2014
    Applicant: PROTELICA, INC.
    Inventors: Guido Cappuccilli, Robert Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 8697608
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: April 15, 2014
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin Type III binding-domain libraries
    Patent number: 8680019
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: March 25, 2014
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 8470966
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: June 25, 2013
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston