Patents Assigned to Protelica, Inc.
  • Universal fibronectin type III binding-domain libraries
    Patent number: 9376483
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: June 28, 2016
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES
    Publication number: 20140135474
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 15, 2014
    Applicant: PROTELICA, INC.
    Inventors: Guido Cappuccilli, Robert Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 8697608
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: April 15, 2014
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin Type III binding-domain libraries
    Patent number: 8680019
    Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: March 25, 2014
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
  • Universal fibronectin type III binding-domain libraries
    Patent number: 8470966
    Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: June 25, 2013
    Assignee: Protelica, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston