Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Type:
Application
Filed:
September 18, 2009
Publication date:
June 17, 2010
Applicant:
ProtElix, Inc.
Inventors:
Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston
Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Type:
Application
Filed:
August 11, 2008
Publication date:
July 9, 2009
Applicant:
ProtElix, Inc.
Inventors:
Guido Cappuccilli, Roberto Crea, Randy Shen, Craig A. Hokanson, Peter B. Kirk, David R. Liston