Patents Assigned to Proteogen, Inc.
  • High-throughput screening method for intergrin antagonist and new peptide screened therefrom
    Patent number: 7604982
    Abstract: The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: October 20, 2009
    Assignee: Proteogen Inc.
    Inventors: Moon-Hi Han, In-Cheol Kang, Yoon-Suk Lee, Soo-Ik Chang
  • High-Throughput Screening Method for Intergrin Antagonist and New Peptide Screened Therefrom
    Publication number: 20070249061
    Abstract: The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.
    Type: Application
    Filed: November 26, 2004
    Publication date: October 25, 2007
    Applicant: Proteogen, Inc.
    Inventors: Moon-Hi Han, In-Cheol Kang, Yoon-Suk Lee, Soo-Ik Chang
  • CALIXCROWN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, A SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES PREPARED BY USING THE SAME AND A PROCESS FOR IMMOBILIZING A PROTEIN MONO-LAYER BY USING THE SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES
    Patent number: 6485984
    Abstract: The present invention is to provide calixcrown derivatives of formulae 1 to 3 requisite for the preparation of a self-assembled monolayer as well as a process for the preparation thereof. Further the present invention is to provide a self-assembled monolayer which is produced by immersing a gold substrate or related metal substrate in an organic solution containing said calixcrown derivatives of formulae 1 to 3. Still further the present invention provides a process for fixing a protein monolayer by fixing proteins having molecular weight of not less than 20,000D (20KD) on said self-assembled monolayer.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: November 26, 2002
    Assignee: Proteogen, Inc.
    Inventor: Tai-Sun Kim