Abstract: The present invention concerns a global maternal serum proteome map and its changes during healthy gestation. Accordingly, the present invention provides an important tool for plasma-based maternal-fetal diagnostics.
Type:
Application
Filed:
January 30, 2009
Publication date:
January 21, 2010
Applicant:
PROTEOGENIX, INC.
Inventors:
SRINIVASA R. NAGALLA, JUHA RASANEN, MICHAEL GRAVETT
Abstract: The present invention concerns the identification and detection of maternal serum biomarkers of pre-eclampsia and associated complications, gestational hypertension and placental insufficiency using global proteomic approaches. The invention further concerns the identification of maternal serum biomarkers for detection of pre-eclampsia and associated complications, gestational hypertension and placental insufficiency during early gestation.
Type:
Application
Filed:
January 30, 2009
Publication date:
January 21, 2010
Applicant:
PROTEOGENIX, INC.
Inventors:
SRINIVASA R. NAGALLA, JUHA RASANEN, MICHAEL GRAVETT
Abstract: The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid (multiple proteins representing the composition of amniotic fluid) and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, or chromosomal defects.
Type:
Grant
Filed:
March 25, 2003
Date of Patent:
March 13, 2007
Assignee:
Proteogenix, Inc.
Inventors:
Ron Rosenfeld, Sri Nagalla, Mike Gravett