Abstract: The disclosure provides, inter alia, methods and reagents for use in measuring the attachment of ubiquitin and ubiquitin-like proteins to a target protein, particularly an E3 protein.
Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
Type:
Grant
Filed:
January 6, 2005
Date of Patent:
September 30, 2008
Assignee:
Proteologics, Inc.
Inventors:
Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
Type:
Application
Filed:
July 30, 2007
Publication date:
August 7, 2008
Applicant:
Proteologics, Inc.
Inventors:
Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
Abstract: The application provides novel complexes of POSH polypeptides and POSH asoociated kinases. The application also provides methods and compositions for treating a POSH-associated diseases such as viral disorders and cancer.
Type:
Application
Filed:
February 5, 2004
Publication date:
November 29, 2007
Applicants:
PROTEOLOGICS, LTD., PROTEOLOGICS. INC.
Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
Type:
Grant
Filed:
January 7, 2005
Date of Patent:
September 11, 2007
Assignee:
Proteologics, Inc.
Inventors:
Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
Type:
Grant
Filed:
November 12, 2002
Date of Patent:
July 31, 2007
Assignee:
Proteologics, Inc.
Inventors:
Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
Abstract: The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as neurological disorders.
Type:
Application
Filed:
April 5, 2004
Publication date:
May 31, 2007
Applicant:
Proteologics, Inc.
Inventors:
Iris Alroy, Yuval Reiss, Daniel Taglicht, Liora Yaar
Abstract: The application relates to inhibitors of POSH-associated E2 enzymes, such as the UBC13/UEV1 complex. Methods of using such RNAi inhibitors for treating viral disorders, such as, for example, HIV infection, are also described.
Abstract: The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as viral disorders, cancer, and neurological disorders.
Type:
Application
Filed:
March 2, 2004
Publication date:
December 21, 2006
Applicant:
Proteologics, Inc.
Inventors:
Daniel Taglicht, Iris Alroy, Yuval Reiss, Liora Yaar, Danny Ben-Avraham, Shmuel Tuvia, Tsvika Greener
Abstract: The application discloses methods and compositions related to the modulation of trans-Golgi network-associated processes, including methods and compositions for the modulation of trans-Golgi network-associated proteins and methods for the treatment of disorders associated with trans-Golgi network processes.
Abstract: The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.
Abstract: The application relates to methods of inhibiting a Nef-mediated process in a cell infected with HIV. The application also provides methods and compositions for treating POSH-associated and HERPUD1-associated diseases such as viral disorders.
Abstract: The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.