Patents Assigned to Proteologics, Ltd.
  • PYRIMIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS
    Publication number: 20130131094
    Abstract: Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.
    Type: Application
    Filed: October 4, 2012
    Publication date: May 23, 2013
    Applicant: PROTEOLOGICS LTD.
    Inventor: Proteologics Ltd.
  • Pyrimidine derivatives as POSH and POSH-AP inhibitors
    Patent number: 8283355
    Abstract: Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: October 9, 2012
    Assignee: Proteologics, Ltd.
    Inventors: Philippe Nakache, Itzchak Angel, Nurit Livnah, Maxim Borovitov
  • PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS
    Publication number: 20120015967
    Abstract: Pyridine and pyrimidine derivatives inhibit ubiquitination of human polypeptides, particularly of POSH and POSH-associated proteins such as HERPUD1, and can be used as medicaments for treatment of viral infections caused by virus such as HIV and for treatment of neurological disorders or diseases.
    Type: Application
    Filed: August 21, 2008
    Publication date: January 19, 2012
    Applicant: PROTEOLOGICS, LTD.
    Inventors: Philippe Nakache, Nurit Livnah
  • Quinazolin-4(3A)-One Derivatives and Methods of Use Thereof
    Publication number: 20110129463
    Abstract: Provided are quinazolin-4(3A)-one derivatives, which are inhibitors of the ubiquitin ligase activity of a human polypeptide, particularly to POSH inhibitors, and to compositions and methods for the treatment RING E3 ubiquitin ligase related diseases.
    Type: Application
    Filed: November 26, 2010
    Publication date: June 2, 2011
    Applicant: Proteologics, Ltd.
    Inventors: Omri EREZ, Philippe NAKACHE
  • PYRIMIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS
    Publication number: 20100179178
    Abstract: Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.
    Type: Application
    Filed: November 7, 2007
    Publication date: July 15, 2010
    Applicant: Proteologics Ltd
    Inventors: Philippe Nakache, Itzchak Angel, Nurit Livnah, Maxim Borovitov
  • Posh Associated Kinases And Related Methods
    Publication number: 20070275368
    Abstract: The application provides novel complexes of POSH polypeptides and POSH asoociated kinases. The application also provides methods and compositions for treating a POSH-associated diseases such as viral disorders and cancer.
    Type: Application
    Filed: February 5, 2004
    Publication date: November 29, 2007
    Applicants: PROTEOLOGICS, LTD., PROTEOLOGICS. INC.
    Inventors: Iris Alroy, Yuval Reiss, Daniel Taglicht, Shmuel Tuvia, Liora Yaar
  • Ubiquitin-based protein interaction assays and related compositions
    Publication number: 20060188890
    Abstract: The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.
    Type: Application
    Filed: October 28, 2004
    Publication date: August 24, 2006
    Applicants: Proteologics, Inc., Proteologics, Ltd.
    Inventors: Shmuel Tuvia, Daniel Taglicht
  • POSH nucleic acids, polypeptides and related methods
    Publication number: 20060035213
    Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
    Type: Application
    Filed: January 6, 2005
    Publication date: February 16, 2006
    Applicant: Proteologics, Ltd.
    Inventors: Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
  • Posh nucleic acids, polypeptides and related methods
    Publication number: 20060019240
    Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
    Type: Application
    Filed: January 7, 2005
    Publication date: January 26, 2006
    Applicant: Proteologics, Ltd.
    Inventors: Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
  • Inhibition of viral maturation, methods and compositions related thereto
    Publication number: 20050214751
    Abstract: The application relates to methods of inhibiting a Nef-mediated process in a cell infected with HIV. The application also provides methods and compositions for treating POSH-associated and HERPUD1-associated diseases such as viral disorders.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 29, 2005
    Applicants: Proteologics, Inc., Proteologics, Ltd.
    Inventors: Yuval Reiss, Iris Alroy
  • Ubiquitin-based protein interaction assays and related compositions
    Publication number: 20050181453
    Abstract: The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.
    Type: Application
    Filed: November 1, 2004
    Publication date: August 18, 2005
    Applicants: Proteologics, Inc., Proteologics, Ltd.
    Inventors: Shmuel Tuvia, Daniel Taglicht