Patents Assigned to Proteologies, Ltd.
  • Pyrimidine derivatives as POSH and POSH-AP inhibitors
    Patent number: 8283355
    Abstract: Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: October 9, 2012
    Assignee: Proteologics, Ltd.
    Inventors: Philippe Nakache, Itzchak Angel, Nurit Livnah, Maxim Borovitov
  • Quinazolin-4(3A)-One Derivatives and Methods of Use Thereof
    Publication number: 20110129463
    Abstract: Provided are quinazolin-4(3A)-one derivatives, which are inhibitors of the ubiquitin ligase activity of a human polypeptide, particularly to POSH inhibitors, and to compositions and methods for the treatment RING E3 ubiquitin ligase related diseases.
    Type: Application
    Filed: November 26, 2010
    Publication date: June 2, 2011
    Applicant: Proteologics, Ltd.
    Inventors: Omri EREZ, Philippe NAKACHE
  • PYRIMIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS
    Publication number: 20100179178
    Abstract: Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.
    Type: Application
    Filed: November 7, 2007
    Publication date: July 15, 2010
    Applicant: Proteologics Ltd
    Inventors: Philippe Nakache, Itzchak Angel, Nurit Livnah, Maxim Borovitov
  • Ubiquitin ligase inhibitors and methods related thereto
    Patent number: 7659277
    Abstract: The application discloses compounds that inhibit ubiquitin ligase activity. The application further discloses antiviral compounds, anticancer compounds, and compounds useful for the treatment of neurological disorders.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: February 9, 2010
    Assignee: Proteologies, Ltd.
    Inventors: Iris Alroy, Shmuel Tuvia, Yuval Reiss, Ofra Levi-Hacham
  • Ubiquitin-based protein interaction assays and related compositions
    Publication number: 20060188890
    Abstract: The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.
    Type: Application
    Filed: October 28, 2004
    Publication date: August 24, 2006
    Applicants: Proteologics, Inc., Proteologics, Ltd.
    Inventors: Shmuel Tuvia, Daniel Taglicht
  • POSH nucleic acids, polypeptides and related methods
    Publication number: 20060035213
    Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
    Type: Application
    Filed: January 6, 2005
    Publication date: February 16, 2006
    Applicant: Proteologics, Ltd.
    Inventors: Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
  • Posh nucleic acids, polypeptides and related methods
    Publication number: 20060019240
    Abstract: The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
    Type: Application
    Filed: January 7, 2005
    Publication date: January 26, 2006
    Applicant: Proteologics, Ltd.
    Inventors: Iris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
  • Inhibition of viral maturation, methods and compositions related thereto
    Publication number: 20050214751
    Abstract: The application relates to methods of inhibiting a Nef-mediated process in a cell infected with HIV. The application also provides methods and compositions for treating POSH-associated and HERPUD1-associated diseases such as viral disorders.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 29, 2005
    Applicants: Proteologics, Inc., Proteologics, Ltd.
    Inventors: Yuval Reiss, Iris Alroy
  • Ubiquitin-based protein interaction assays and related compositions
    Publication number: 20050181453
    Abstract: The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.
    Type: Application
    Filed: November 1, 2004
    Publication date: August 18, 2005
    Applicants: Proteologics, Inc., Proteologics, Ltd.
    Inventors: Shmuel Tuvia, Daniel Taglicht