Abstract: The present invention provides materials and methods relating to screening for compounds useful in the treatment of Alzheimer's disease and related conditions. In particular, screening methods using tyrosine kinases are provided, as are methods relating to the role of tyrosine kinases as therapeutic targets.
Type:
Application
Filed:
August 17, 2015
Publication date:
June 30, 2016
Applicants:
Proteome Sciences plc, King's College London
Inventors:
Malcolm Ward, Helen Byers, Brian Henry Anderton, Pascal Derkinderen, Christopher Hugh Reynolds, Ritchie Williamson
Abstract: Methods of screening for candidate compounds capable of inhibiting activity of fyn in phosphorylating tau protein at Y394 or binding to fyn to inhibit interaction with tau protein at Y394, including determining whether, and optionally the extent, the candidate compounds have these capabilities under conditions where fyn has these capabilities in the absence of the candidate compound. Methods of screening for substances capable of promoting dephosphorylation of tau protein by a phosphatase at a site of tau protein including contacting a candidate substance, the tau protein and a phosphatase capable of dephosphorylating the tau protein under conditions where the phosphatase is capable of dephosphorylating the site in absence of the candidate substance, where the kinase is fyn; determining whether, and optionally the extent, the candidate substance promotes dephosphorylation of the tau protein at the site; and selecting the candidate substance which promotes dephosphorylation of the tau protein the sites.
Type:
Application
Filed:
July 24, 2014
Publication date:
February 19, 2015
Applicants:
Proteome Sciences PLC, King's College London
Inventors:
Brian Anderton, Diane Hanger, Malcolm Ward, Helen Byers
Abstract: Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
Type:
Grant
Filed:
August 26, 2005
Date of Patent:
February 25, 2014
Assignee:
Proteome Sciences plc
Inventors:
Malcolm Ward, Vaksha Patel, Emma McGregor, Nicola Leeds, Helen Byers, James Campbell, Kit-Yi Leung, Jules Westbrook
Abstract: The present invention provides materials and methods relating to screening for compounds useful in the treatment of Alzheimer's disease and related conditions. In particular, screening methods using tyrosine kinases are provided, as are methods relating to the role of tyrosine kinases as therapeutic targets.
Type:
Application
Filed:
November 21, 2012
Publication date:
May 16, 2013
Applicants:
KING'S COLLEGE LONDON, PROTEOME SCIENCES PLC
Inventors:
Proteome Science plc, King's College London
Abstract: The present invention provides methods of screening for candidate compounds useful in the treatment of Alzheimer's disease and related conditions by inhibiting specific phosphorylation of tau protein by tyrosine kinase c-Abl.
Type:
Grant
Filed:
June 21, 2005
Date of Patent:
February 5, 2013
Assignees:
Proteome Sciences plc, King's College London
Inventors:
Malcolm Ward, Helen Byers, Brian Henry Anderton, Pascal Derkinderen, Christopher Hugh Reynolds, Ritchie Williamson
Abstract: An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having an organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are disclosed, along with cells for making such antibodies. Methods of making and using such antibody microarrays are also disclosed.
Type:
Grant
Filed:
December 24, 2003
Date of Patent:
December 13, 2011
Assignee:
Proteome Sciences PLC
Inventors:
Christopher D. J. Pearce, Lloyd G. Mitchell
Abstract: This invention relates to the use of extracts and compounds derived from the plant Aristolochia taliscana and their analogues in the treatment of AIDS.
Type:
Application
Filed:
January 31, 2001
Publication date:
July 25, 2002
Applicant:
PROTEOME SCIENCES PLC
Inventors:
Hans Achenbach, Carlos Navarro, Alejandro Navarro