Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Multiplexed assays using the surface detector array device of the present invention are disclosed, as are automated methods for making the surface detector array device that enable formation of arrays wherein the composition of the individual, addressable bilayer regions is unrestricted.
Type:
Grant
Filed:
July 22, 2002
Date of Patent:
March 2, 2004
Assignee:
Proteomic Systems, Inc.
Inventors:
Miki (Vikky) Yamazaki, Morrison Ulman, Luat T. Nguyen, Steven G. Boxer, John T. Groves
Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Multiplexed assays using the surface detector array device of the present invention are disclosed, as are automated methods for making the surface detector array device that enable formation of arrays wherein the composition of the individual, addressable bilayer regions is unrestricted.
Type:
Application
Filed:
July 22, 2002
Publication date:
May 22, 2003
Applicant:
Proteomic Systems, Inc.
Inventors:
Miki Yamazaki, Morrison Ulman, Luat T. Nguyen, Steven G. Boxer, John T. Groves