Abstract: The invention relates to a process that allows electrolytic copper cathodes to be produced, using the pregnant leach solution (PLS) directly in the electrowinning, avoiding the step of mineral concentration by solvent extraction. Furthermore, this process has a modular structure and the full process can be mobilised depending on the requirements of the process itself. The invention also relates to the system that operates with the previously described process.

Abstract: A therapeutic treatment for the athrosis diseases comprising administering by intraarticular route from 1 to 5 ml of an aqueous solution containing from 10 to 50 mg of a diacetyl rhein salt having formula (I): ##STR1## wherein M represents an alkali or an earth alkali metal or the residue of an organic base.The diacetyl rhein salts administered by intraarticular route exhibit higher pharmacological activity than the corresponding diacetylrhein administered orally.

Abstract: Several methods are disclosed for the preparation of oral pharmaceutical forms with delayed release of rhein and its derivatives. The pharmaceutically active ingredient is provided in the form of granules, coated with at least one of polyvinylpyrrolidone, shellac and hydroxypropylmethyl cellulose. The desired effect of the coating is to slow release of the pharmaceutically active ingredient by resisting gastric juices in the stomach, but gradually dissolving in the intestines.

Abstract: A pharmaceutical composition for use in the treatment of malignant tumor cells in laboratory animals is disclosed. The pharmaceutical composition uses a pharmaceutically acceptable excipient with a tripeptide compound as the active ingredient. The tripeptide compound is formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine, and methione.

Abstract: The cancericidal activity of all the permutations of a tripeptide compound formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine and methionine bonded together with peptide links was demonstrated using seven in vitro tumor cell lines. The viabilities of each of the tumor cell lines were significantly reduced by treatment for 1 to 24 hours with 1 to 50 ug of the tripeptide per ml of carrier solvent. A pulse exposure to the tripeptide demonstrated that the reductions in tumor cell was comparable to continuous exposure. Other in vitro tests were all conducted on AKR mice.Methods of treating virus by exposing the virus to one of the noted tripeptide compounds is also contemplated.Methods of treating tumor cells with the tripeptides dissolved in a solvent consisting of dimethylacetamide, propylene glycol and absolute ethanol are also contemplated by the present invention.

Abstract: The cancericidal activity of all the permutations of a tripeptide compound formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine and methionine bonded together with peptide links was demonstrated using seven in vitro tumor cell lines. The viabilities of each of the tumor cell lines were significantly reduced by treatment for 1 to 24 hours with 1 to 50 .mu.g of the tripeptide per ml of carrier solvent. A pulse exposure to the tripeptide demonstrated that the reductions in tumor cell was comparable to continuous exposure. Other in vitro tests were all conducted on AKR mice.Methods of treating virus by exposing the virus to one of the noted tripeptide compounds is also contemplated.Methods of treating tumor cells with the tripeptides dissolved in a solvent consisting of dimethylacetamide, propylene glycol and absolute ethanol are also contemplated by the present invention.

Abstract: A process for preparing Tetroxoprim starting from 3,5-dimethoxy-4-methoxyethoxy-benzaldehyde and 2,4-diamino-6-hydroxy-pyrimidine, by successive hydrogenation, halogenation and hydrogenolysis of the 2,4-diamino-6-oxo-5-(3,5-dimethoxy-4-methoxyethoxy-benzylidene)-pyrimidine obtained in the initial reaction.

Abstract: Compounds with high anti-tumor activity and of moderate toxicity are described which are constituted by tripeptides formed from dichlorodiethylaminophenylalanine, para-fluorophenylalanine and methionine bonded together by peptide links.The tripeptides of the invention are particularly useful in the treatment of malignant tumors.

Abstract: N-acyl derivatives of D-hexosamine made by linking an oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl residue to the amino groups of two hexosamine molecules by a peptide bond, are endowed with strong antitumor action against transplanted neoplasms in animals. Compounds according to the present invention are: ##STR1## and its salts with organic or inorganic acids physiologically tolerated. The antineoplastic activity of the compounds of the present invention is not affected in the gastrointestinal tract and hence they can be effectively administered orally.

Abstract: 1,8-Dihydroxy and 1,8-diacetoxy anthraquinones and derivatives thereof are used to treat the symptoms of arthritis.

Abstract: N-Acyl derivatives of glucosamines made by linking an amino acid or oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl group, to the amino group of the glucosamines by a peptide bond, are endowed with strong anti-tumor action against transplanted neoplasma in animal. The compounds according to the present invention are of the general formula (I): ##STR1## where R.sub.1 is a hydrogen atom or an acetyl group,R.sub.2 is a hydrogen atom, an acetyl group, aliphatic (C.sub.1 -C.sub.6) group or a benzyl groupand R.sub.3 is m-di(2-chloroethyl) amino-L-phenylalanine, or L- methionyl -m-di(2-chloroethyl) amino-L-phenylalanyl-p-fluoro-L-phenylalanine, or p-fluoro-L-phenylalanyl-m-di (2-chloroethyl) amino-L-phenylalanyl-L-proline, or m-di (2-chloroethyl) amino-L-phenylalanyl-L-methionyl-p-fluoro-L-phenylalanine.The antineoplasmic activity of the compounds of the present invention is not affected in the gastrointestinal tract and hence they can be effectively administered orally.