Patents Assigned to Proteus Biomedical, Inc.
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Publication number: 20100114234Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: November 23, 2009Publication date: May 6, 2010Applicant: Proteus Biomedical, Inc.Inventor: Mark J. Zdeblick
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Publication number: 20100081894Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.Type: ApplicationFiled: September 21, 2009Publication date: April 1, 2010Applicant: PROTEUS BIOMEDICAL, INC.Inventors: Mark Zdeblick, Timothy Robertson, Aleksandr Pikelny, Hooman Hafezi
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Patent number: 7637867Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: GrantFiled: March 29, 2007Date of Patent: December 29, 2009Assignee: Proteus Biomedical, Inc.Inventor: Mark J. Zdeblick
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Patent number: 7640060Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: GrantFiled: March 29, 2007Date of Patent: December 29, 2009Assignee: Proteus Biomedical, Inc.Inventor: Mark J. Zdeblick
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Publication number: 20080312726Abstract: Implantable hermetically sealed structures and methods for making the same are provided. Also provided are devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems.Type: ApplicationFiled: December 22, 2005Publication date: December 18, 2008Applicant: PROTEUS BIOMEDICAL, INC.Inventors: Jeremy Frank, Vladimir Gelfandbein, Marc Jensen, Mark Zdeblick, Benedict J. Costello
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Publication number: 20080294218Abstract: One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.Type: ApplicationFiled: March 31, 2006Publication date: November 27, 2008Applicant: PROTEUS BIOMEDICAL, INC.Inventors: George M. Savage, Todd Thompson, Mark J. Zdeblick, Lawrence W. Arne, Olivier Colliou, Benedict James Costello, Fataneh A. Omidvar
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Publication number: 20080284599Abstract: Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.Type: ApplicationFiled: April 28, 2006Publication date: November 20, 2008Applicant: PROTEUS BIOMEDICAL, INC.Inventors: Mark Zdeblick, Andrew Thompson, Aleksandr Pikelny, Timothy Robertson
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Publication number: 20080255629Abstract: Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.Type: ApplicationFiled: October 31, 2005Publication date: October 16, 2008Applicant: PROTEUS BIOMEDICAL, INC.Inventors: Marc Jenson, Todd Thompson, Olivier Colliou, George M. Savage, Mark J. Zdeblick, Jeremy Frank, Lawrence W. Arne, Robert White
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Patent number: 7398688Abstract: Implantable pressure sensors and methods for making and using the same are provided. A feature of embodiments of the subject pressure sensors is that they are low-drift sensors. The subject sensors find use in a variety of applications.Type: GrantFiled: December 13, 2006Date of Patent: July 15, 2008Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Lawrence Arne, Nilay Jani, Haifeng Li
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Publication number: 20080154328Abstract: Implantable connector arrangements are provided for allowing a plurality of electrode leads to be connected to an implantable device through a single port in the device. Also provided are leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, and methods of making and using the subject devices.Type: ApplicationFiled: December 14, 2007Publication date: June 26, 2008Applicant: PROTEUS BIOMEDICAL, INC.Inventors: Todd THOMPSON, Benedict J. COSTELLO, George M. SAVAGE
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Publication number: 20080027289Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: January 31, 2008Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Patent number: 7284441Abstract: Implantable pressure sensors and methods for making and using the same are provided. A feature of embodiments of the subject pressure sensors is that they are low-drift sensors. The subject sensors find use in a variety of applications.Type: GrantFiled: December 28, 2004Date of Patent: October 23, 2007Assignee: Proteus Biomedical, Inc.Inventor: Mark J. Zdeblick
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Patent number: 7267649Abstract: A cardiac sensor system includes implanted cardiac sensor assemblies and an external controller which receives information from the implanted sensors. The sensors permit direct measurement of a number of physiologic parameters. The external controller permits calculation of a variety of performance values based on the measured physiological parameters. Optionally, patient oxygen consumption can be measured externally and combined with the internally measured physiologic parameters in order to calculate a variety of unique performance values.Type: GrantFiled: January 23, 2004Date of Patent: September 11, 2007Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Joseph M. Ruggio
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Publication number: 20070185537Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 9, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070185549Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 9, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070185548Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 9, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070179569Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 2, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070173897Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: July 26, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Patent number: 7214189Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: GrantFiled: September 1, 2005Date of Patent: May 8, 2007Assignee: Proteus Biomedical, Inc.Inventor: Mark J. Zdeblick
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Patent number: 7204798Abstract: Methods and systems of the present invention provide for measurement of various cardiac parameters. Methods generally involve causing a change in volume and/or pressure in a heart chamber, measuring the change, and calculating at least one cardiac parameter based on the change. Systems typically include at least one actuator, at least one sensor, and a catheter or other device for positioning at least partially in a heart chamber. In some embodiments, the system may also include a controller, such as a computer or other processor, an external actuator, an external sensor, and/or an ECG device. Methods and systems of the invention may be used to more accurately diagnose cardiac conditions in order to make more informed treatment decisions.Type: GrantFiled: January 23, 2004Date of Patent: April 17, 2007Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Joseph M. Ruggio