Patents Assigned to Protexeon Limited
  • USE OF XENON AS NEUROPROTECTANT IN A NEONATAL SUBJECT
    Publication number: 20090311340
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for preventing and/or alleviating one or more anesthetic-induced neurological deficits in a neonatal subject. The present invention further relates to combinations of xenon and sevoflurane, and use thereof as preconditioning agents for administration prior to hypoxic-ischaemic injury.
    Type: Application
    Filed: August 19, 2005
    Publication date: December 17, 2009
    Applicant: PROTEXEON LIMITED
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Analgesic agent for newborn or fetal subjects
    Patent number: 7632872
    Abstract: In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: December 15, 2009
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Use of xenon for the control of neurological deficits associated with cardiopulmonary bypass
    Patent number: 7442383
    Abstract: The present invention relates to methods of controlling neurological deficits in patients who have undergone cardiopulmonary bypass (CPB) by administering xenon to said patients.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: October 28, 2008
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Use of xenon with hypothermia for treating neonatal asphyxia
    Patent number: 7390508
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for the treatment of neonatal asphyxia in a neonatal subject, wherein said medicament is for use in combination with hypothermia.
    Type: Grant
    Filed: October 11, 2004
    Date of Patent: June 24, 2008
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Use of xenon with hypothermia for treating neonatal asphyxia
    Publication number: 20070104796
    Abstract: The present invention relates to the use of xenon in the preparation of a medicament for the treatment of neonatal asphyxia in a neonatal subject, wherein said medicament is for use in combination with hypothermia.
    Type: Application
    Filed: October 11, 2004
    Publication date: May 10, 2007
    Applicant: PROTEXEON LIMITED
    Inventors: Nicholas Franks, Mervyn Maze
  • NMDA antagonist comprising xenon
    Patent number: 6653354
    Abstract: The present invention relates to the use of xenon as a neuroprotectant and/or as an inhibitor of synaptic plasticity. In a preferred aspect, the xenon acts as an NMDA antagonist. The present invention also provides a method of reducing the level of activation of the NMDA receptors in a mammal, the method comprising modulating the activity of the NMDA receptor by administering to the mammal a therapeutically effective amount of xenon, wherein said reduction achieves neuroprotection and/or an inhibition of synaptic plasticity. A further embodiment of the invention provides a pharmaceutical composition for providing neuroprotection and/or inhibition of synaptic plasticity, together with a process for the preparation thereof.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: November 25, 2003
    Assignee: Protexeon Limited
    Inventors: Nicholas Peter Franks, Mervyn Maze