Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
Type:
Application
Filed:
May 29, 2018
Publication date:
December 20, 2018
Applicants:
PROTHENA THERAPEUTICS LIMITED, UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
Inventors:
DALE B. SCHENK, PETER A. SEUBERT, JONATHAN WALL, JOSÉ SALDANHA
Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
Type:
Application
Filed:
May 20, 2016
Publication date:
March 23, 2017
Applicants:
PROTHENA THERAPEUTICS LIMITED, UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
Inventors:
DALE B. SCHENK, PETER A. SEUBERT, JONATHAN WALL, JOSÉ SALDANHA