Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.
Type:
Grant
Filed:
May 29, 2012
Date of Patent:
January 28, 2014
Assignee:
Protherics Medicines Development Limited
Inventors:
Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
Abstract: The present invention includes a formulation comprising a physiological salt solution, or an oil-in-water emulsion, or a water immiscible solid phase, and an adjuvant comprising one or more disaccharide derivatives derived from cellobiose, gentiobiose, lactose, lactulose, maltose, melibiose, sucrose or turanose, wherein at least four of the free hydroxyl groups of the disaccharide molecule have been modified such that the disaccharide derivative has: (i) at least 3, but not more than N-1, fatty acid ester groups, wherein each of the fatty acid ester groups is represented by a general formula of —O—C(?O)—(CH2)xCH3 wherein x is between 6 and 14, and (ii) at least one, but no more than N-1 anionic groups, wherein N is the number of hydroxyl groups of the disaccharide from which the derivative is derived and wherein the combined number of fatty acid esters and anionic groups does not exceed N.
Type:
Grant
Filed:
April 20, 2009
Date of Patent:
November 8, 2011
Assignee:
Protherics Medicines Development Limited
Inventors:
Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
Abstract: Synthetic polypeptides having at least one antigenic site of a prior protein, methods for their use and manufacture, antibodies raised against such polypeptides and diagnostic kits containing these polypeptides or antibodies.
Type:
Grant
Filed:
April 5, 2002
Date of Patent:
August 17, 2010
Assignee:
Protherics Medicines Development Limited
Inventors:
Robert Vincent Fishleigh, Barry Robson, Roger Paul Mee
Abstract: An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system.
Type:
Application
Filed:
April 24, 2008
Publication date:
April 23, 2009
Applicant:
Protherics Medicines Development Limited
Inventors:
James Francis Glover, Arthur Rushton, Phillip John Morgan, Stephen Clinton Young
Abstract: An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system.
Type:
Grant
Filed:
December 23, 1999
Date of Patent:
May 27, 2008
Assignee:
Protherics Medicines Development Limited
Inventors:
James Francis Glover, Arthur Rushton, Phillip John Morgan, Stephen Clinton Young
Abstract: A method of combating toxicity caused by an antifolate compound of Formula I, in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual.
Type:
Application
Filed:
February 28, 2005
Publication date:
October 18, 2007
Applicant:
Protherics Medicines Development Limited