Abstract: A method of forming a metadatabase of minimal epitope profiles including: performing antibody activity profiling from an immunoglobulin fraction of a plurality of samples to form a data set of peptide profiles for each sample, comparing peptide profiles across different samples, assigning a diagnosis or disorder to differentially expressed meta-profiles, constructing a meta-database containing minimal epitope clusters, constructing a database of peptide frequencies, aligning peptides to define the sequence of minimal epitope, verifying the minimal epitope by harboring a connected identifier, providing an enriched affinity sample, and providing a source data for metadatabase a database underlying it.

Abstract: Methods of stimulating multipotency, proliferation and differentiation of isolated mesenchymal stem cells (MSCs), which permit more effective differentiation and integration of such cells into host tissues. The method includes providing an in vitro cell population of MSCs and administering CCL5 chemokine. Preferably CCL is administered in an amount sufficient to induce expression of one or more multipotency related genes selected from the group consisting of OCT3/4, NANOG, SOX 2, KLF4, and SOX9.