Patents Assigned to PROTON OOO
  • Patent number: 9453008
    Abstract: The invention relates to the field of chemical and pharmaceutical industry and medicine and concerns compounds which can be used to produce agents for the treatment of cardiovascular diseases. The use of 2-[2-cyano-2-[5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-ylidene]ethylidene]indolin-3-one of formula I is proposed as a biologically active compound exhibiting the properties of exogenous nitric oxide donor, a platelet aggregation inhibitor, also exhibiting antihypertensive activity and activating activity towards the soluble guanylate cyclase enzyme. Variants of methods for synthesizing the above compound are also proposed.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: September 27, 2016
    Assignee: PROTON OOO
    Inventors: Svetlana Yurevna Ryabova, Valery Aleksandrovich Parshin, Vladimir Grigorevich Granik, Nikita Borisovich Grigoriev, Ludmila Mikhaylovna Alekseeva
  • Publication number: 20140235868
    Abstract: The invention relates to the field of chemical and pharmaceutical industry and medicine and concerns compounds which can be used to produce agents for the treatment of cardiovascular diseases. The use of 2-[2-cyano-2-[5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-ylidene]ethylidene]indolin-3-one of formula I is proposed as a biologically active compound exhibiting the properties of exogenous nitric oxide donor, a platelet aggregation inhibitor, also exhibiting antihypertensive activity and activating activity towards the soluble guanylate cyclase enzyme. Variants of methods for synthesizing the above compound are also proposed.
    Type: Application
    Filed: October 29, 2012
    Publication date: August 21, 2014
    Applicant: PROTON OOO
    Inventors: Svetlana Yurevna Ryabova, Valery Aleksandrovich Parshin, Vladimir Grigorevich Granik, Vladimir Vladimirovich Grank, Nikta Borisovich Grigoriev, Ludmila Mikhaylovna Aleksseva