Patents Assigned to Provasculon, Inc.
  • METHODS FOR REPAIRING TISSUE DAMAGE USING PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1
    Publication number: 20140199304
    Abstract: The present invention features methods for treating or ameliorating tissue damage using intravenous administration of compositions that include stromal cell derived factor-1 (SDF-1) peptides or mutant SDF-1 peptides that have been mutated to make them resistant to protease digestion, but which retain chemoattractant activity. Systemic delivery, and specifically intravenous (“IV”) delivery, of SDF-1 and protease resistant SDF-1 mutants is very effective for the treatment of tissue damage.
    Type: Application
    Filed: June 6, 2012
    Publication date: July 17, 2014
    Applicant: Provasculon, Inc.
    Inventors: Anthony Sandrasagra, Weitao Wu
  • PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
    Publication number: 20110224139
    Abstract: The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.
    Type: Application
    Filed: February 17, 2011
    Publication date: September 15, 2011
    Applicant: Provasculon, Inc.
    Inventors: Vincent Frans Maria Segers, Anthony Sandrasagra, Yan Qiu