Patents Assigned to Providence Health System
  • Patent number: 10552960
    Abstract: A system and method of displaying of multiple simultaneous views of a same region of a biological tissue sample. Logical instructions are executed by a processor to perform operations such as receiving a plurality of images of the biological tissue sample, converting the plurality of images to a common reference frame based on the individual metadata of each image, and arranging the plurality of images into a display pattern for simultaneous viewing of different aspects of the imaged biological tissue sample on a display screen. The plurality of images is produced by preprocessing images of the biological tissue sample. Each image shows a view mode of a same region of the biological tissue sample, and each image contains metadata that describe spatial orientation, such as the translation, rotation, and magnification, of the image to bring the plurality of images to a common view.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: February 4, 2020
    Assignees: Ventana Medical Systems, Inc., Providence Health & Services—Oregon
    Inventors: Michael Barnes, Carlo Bifulco, Christophe Chefd'hotel, Ting Chen, Alisa Tubbs
  • Patent number: 8652836
    Abstract: Methods are disclosed for producing defective ribosomal products (DRiPs) in blebs (DRibbles) by contacting cells with a proteasome inhibitor, and in some examples also an autophagy inducer, thereby producing treated cells. DRibbles can be used to load antigen presenting cells (APCs), thereby allowing the APCs to present the DRiPs and antigenic fragments thereof. Immunogenic compositions that include treated cells, isolated DRibbles, or DRibble-loaded APCs are also disclosed. Methods are also provided for using treated cells, isolated DRibbles, or DRibble-loaded APCs to stimulate an immune response, for example in a subject. For example, DRibbles obtained from a tumor cell can be used to stimulate an immune response against the same type of tumor cells in the subject. In another example, DRibbles obtained from a pathogen-infected cell or cell engineered to express one or more antigens of a pathogen can be used to stimulate an immune response against the pathogen in the subject.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: February 18, 2014
    Assignee: Providence Health System
    Inventor: Hong-Ming Hu
  • Publication number: 20110274726
    Abstract: The invention provides a solid foam wound dressing useful for hemorrhage control and wound repair, as well as methods for making such a wound dressing.
    Type: Application
    Filed: October 6, 2009
    Publication date: November 10, 2011
    Applicant: PROVIDENCE HEALTH SYSTEM - OREGON
    Inventors: Jian Xin Guo, Kenton W. Gregory
  • Patent number: 7959925
    Abstract: Compositions including a trimeric OX-40 fusion protein are disclosed. Also disclosed are methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells involving administering to the mammal a composition comprising a trimeric OX-40 fusion protein and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: June 14, 2011
    Assignee: Providence Health System
    Inventors: Andrew D. Weinberg, Nicholas P. Morris, Carmen Romerdaue
  • Patent number: 7820872
    Abstract: A chitosan biomaterial is frozen in aqueous solution to form a frozen chitosan structure from which water is removed by a prescribed freeze-drying process to form a sponge-like chitosan structure having a thickness and a density. The sponge-like chitosan structure is compressed by application of heat and pressure to reduce the thickness and increase the density of the sponge-like chitosan structure to form a densified chitosan structure. The densified chitosan structure is further preconditioned by heating the densified chitosan structure according to prescribed conditions to form a wound dressing. The wound dressing possesses an adhesion strength and resistance to dissolution in high blood flow bleeding situations.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 26, 2010
    Assignee: Providence Health System-Oregon
    Inventors: Kenton W Gregory, Simon McCarthy
  • Publication number: 20090192825
    Abstract: A process and/or system that extracts selected information from e.g. traditional electronics medical records to enable analysis of a determined medical condition shared by multiple patients. A data warehouse receives the extracted information and reformats that information to enable rapid analysis by a health care provider of that provider's patient population having that medical condition. It further collects the selective data of the selected patients for multiple health care providers and enables comparisons of health care providers' success for such patients to promote upgrading of the treatment by less successful providers.
    Type: Application
    Filed: March 12, 2009
    Publication date: July 30, 2009
    Applicant: Providence Medical Group, a Division of Providence Health System-Oregon
    Inventors: Jacquelyn Suzanne Hunt, Joseph Siemienczuk
  • Publication number: 20090169593
    Abstract: A device implantable within a human body, and a method for producing the device, are provided. The device comprises a biocompatible coating on at least a portion of an outer surface of a substrate. The biocompatible coating comprises tropoelastin. A biocompatible coating is formed in situ on the outer surface of the substrate.
    Type: Application
    Filed: October 19, 2006
    Publication date: July 2, 2009
    Applicants: BIOMEDICAL RESEARCH SERVICES, INC., PROVIDENCE HEALTH SYSTEMS - Oregon, an Oregon Nonprofit Corporation
    Inventors: Kenton W. Gregory, Robert Glanville, Hooi-Sung Kim, Rui-Qing Qian, Carl Wamser
  • Publication number: 20090164249
    Abstract: A customizable patient management system, comprising of a patient database including a plurality of patient specific care parameters, a user-interface to select a one or more patient specific care parameters for sorting the patient database, and a data processing system, configured to sort the patient database based on the selected care parameters and display a set of patients corresponding to the selected care parameters where the set of patients may be at risk for or have a common health condition.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 25, 2009
    Applicant: PROVIDENCE MEDICAL GROUP, A DIVISION OF PROVIDENCE HEALTH SYSTEM - OREGON
    Inventors: Jacquelyn Suzanne Hunt, Joseph Siemienczuk
  • Publication number: 20090164237
    Abstract: A patient management system, comprising of a care provider interface, configured to receive a selection of a plurality of individual patients and a data processing system, configured to automatically generate a plurality of personalized patient-specific communications based on the selection, the communication directed to individual selected patients, each patient communication including at least one personalized patient care parameter specific to the individual selected patient.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 25, 2009
    Applicant: PROVIDENCE MEDICAL GROUP, a Division of Providence Health System - Oregon
    Inventors: Jacquelyn Suzanne Hunt, Joseph Siemienczuk
  • Publication number: 20090164248
    Abstract: A patient management system, comprising of a care provider interface, configured to receive a selection of a plurality of patients and a data processing system configured to signal whether to exclude an individual patient within a subset of the plurality of patients based on an intervention parameter and further configured to send a communication to each of the patients in the subset.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 25, 2009
    Applicant: PROVIDENCE MEDICAL GROUP, A DIVISION OF PROVIDENCE HEALTH SYSTEM
    Inventors: Jacquelyn Suzanne Hunt, Joseph Siemienczuk
  • Patent number: 7523042
    Abstract: A process and/or system that extracts selected information from e.g. traditional electronics medical records to enable analysis of a determined medical condition shared by multiple patients. A data warehouse receives the extracted information and reformats that information to enable rapid analysis by a health care provider of that provider's patient population having that medical condition. It further collects the selective data of the selected patients for multiple health care providers and enables comparisons of health care providers' success for such patients to promote upgrading of the treatment by less successful providers.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: April 21, 2009
    Assignee: Providence Medical Group, a division of Providence Health System - Oregon
    Inventors: Jacquelyn Suzanne Hunt, Joseph Siemienczuk
  • Patent number: 7482503
    Abstract: This invention is directed to advanced hemorrhage control wound dressings, and methods of using a producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing is formed of a biomaterial comprising chitosan for controlling severe bleeding. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot information at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: January 27, 2009
    Assignees: Providence Health System-Oregon
    Inventors: Kenton W Gregory, Simon McCarthy
  • Patent number: 7371403
    Abstract: This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 13, 2008
    Assignees: Providence Health System-Oregon
    Inventors: Simon J. McCarthy, Kenton W. Gregory, William P. Wiesmann, Todd D. Campbell
  • Patent number: 7322932
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises method for suturelessly attaching a biomaterial suturelessly bonded to the A method for securing a biomaterial to a valve frame includes positioning a flexible valve frame defining an open area on a first major surface of a biomaterial sheet having a peripheral edge, wherein positioning serves to approximate the valve frame and the peripheral edge of the biomaterial sheet to form an at least first bonding locus; and suturelessly bonding the biomaterial to the valve frame at the at least first bonding locus. The method avoids the disadvantages associated with conventional sutures and substantially reduces medical complications in implantations.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: January 29, 2008
    Assignee: Providence Health System - Oregon
    Inventors: Hua Xie, Lisa A. Buckley
  • Patent number: 7166124
    Abstract: A bioprosthetic stent graft is disclosed, having a stent frame and a biomaterial sheath suturelessly bonded to the stent frame. Sutureless bonding avoids sutures and substantially reducing medical complications in implantation of the stent graft. A device and method for manufacturing the stent graft further is disclosed. A mandrel is employed for shaping the stent graft, and means for irradiating the biomaterial effects sutureless bonding.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: January 23, 2007
    Assignee: Providence Health System - Oregon
    Inventors: Hua Xie, Lisa A. Buckley
  • Patent number: 7163556
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises a biomaterial suturelessly bonded to the valve frame, avoiding sutures and substantially reducing medical complications in implantations.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: January 16, 2007
    Assignee: Providence Health System - Oregon
    Inventors: Hua Xie, Lisa A. Buckley
  • Patent number: 7088455
    Abstract: Methods for measuring strains in biological and other samples include illuminating a specimen with substantially collimated laser flux. An electro-acoustic transducer is activated to generate acoustic waves in the specimen, including a surface wave component such as a Rayleigh wave. A series of laser speckle patterns produced by a laser flux scattered or reflected by the specimen is recorded and speckle pattern shifts are calculated based on the recorded speckle patterns. Phase shifts produced by acoustic wave propagation in the specimen are used to identify specimen regions associated with irregularities such as inclusions, cracks, or tissue abnormalities. In some examples, specimens are stretched or otherwise stressed by one or more light fluxes, and specimen elongation is estimated based on a series of associated speckle patterns.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: August 8, 2006
    Assignee: Providence Health Systems —Oregon
    Inventors: Sean J. Kirkpatrick, Donald D. Duncan
  • Patent number: 7079257
    Abstract: Methods for measuring strains in circuit substrates such as circuit boards and semiconductor wafers include illuminating a specimen with a substantially collimated laser flux. A temperature change is produced in the specimen and a series of laser speckle patterns produced by a laser flux scattered or reflected by the specimen is recorded. Localized strains are detected based on speckle pattern shifts that are calculated using the recorded speckle patterns. Stains can be recorded as a function of temperature or rate of change of temperature, and strains at one or more circuit substrate locations can be detected.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: July 18, 2006
    Assignee: Providence Health System
    Inventors: Sean J. Kirkpatrick, Donald D. Duncan
  • Patent number: 7001328
    Abstract: It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue using tropoelastin, preferably crosslinked tropoelastin and specifically to provide a tropoelastin biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The tropoelastin biomaterial itself can also be used as a stent or conduit covering or coating or lining.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: February 21, 2006
    Assignees: Providence Health Systems-Oregon
    Inventors: Andrew D. Barofsky, Kenton W. Gregory
  • Patent number: RE43134
    Abstract: The present invention provides a denatured albumin lamina, useful for repairing lesions on solid visceral organs. The lamina comprises human serum albumin, formed into a thin, pliant sheet and denatured. The denatured lamina can be sterilized and stored until used. As well, it can be impregnated with a variety of bioagents. A method for repairing a lesion on a solid visceral organ includes applying an energy-absorbing proteinaceous material to a lesion site on the solid visceral organ lesion; irradiating the proteinaceous material with energy sufficient to fuse the energy-absorbing material at least partially to the lesion site; applying a biocompatible denatured albumin lamina onto the proteinaceous material on the lesion site; and irradiating the biocompatible albumin lamina and the proteinaceous material with energy sufficient to fuse the biocompatible albumin lamina to the proteinaceous material and/or the lesion site.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: January 24, 2012
    Assignee: Providence Health System - Oregon
    Inventors: Yasmin Wadia, Scott Alan Prahl