Patents Assigned to Proviva Therapeutics (Hong Kong) LImited
  • IL-2 COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20220378933
    Abstract: Provided are activatable proprotein homodimers, comprising at least two separate polypeptide chains, each chain comprising an IL-2 protein variant that has reduced binding affinity to wild-type IL-2R? relative to that of the wild-type IL-2 sequence, a cleavable linker, and an IL-2 binding protein, among other optional features, and related pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 1, 2022
    Applicant: Proviva Therapeutics (Hong Kong) LImited
    Inventors: Zijuan LI, Hongxing ZHOU