Patents Assigned to Proxeon Biosystems A/S
-
Patent number: 9285348Abstract: An automated system for handling components of a chromatographic system, comprising: one or more trap columns each having sorbent material therein; a robotic system for moving a trap column from a storage position to an operating position where the trap column is connected in a liquid pathway along which solvent is flowed in operation to a liquid chromatography (LC) column; and an optical sensor for sensing one or more parameters of the trap column. Sensed parameters can include: a presence or absence of a trap column in the operating position, a position or orientation of the trap column, a fluid level in the trap column, the presence and position of a sorbent material in the trap column, the condition of the trap column and/or whether the trap column is new or used.Type: GrantFiled: October 31, 2013Date of Patent: March 15, 2016Assignee: Proxeon Biosystems A/SInventor: Soeren Theodorsen
-
Publication number: 20150198571Abstract: The present invention relates to an integrated system for liquid separation, such as LC, CE, affinity chromatography, and ion exchange chromatography. A preferred aspect relates to a specialised protection means for protecting the fragile electrospray needle when not in use. Another preferred aspect relates to a specialised electrical contact means for applying voltage to the electrospray needle. The invention comprises an integrated system for liquid separation and electrospray ionization comprising: a separation column; and an electrospray emitter connected with the separation column. In one aspect there is a retractable protective sleeve (8) for covering and supporting the electrospray emitter (2) along at least a portion of its axis. In another aspect there is an electrically conducting sheath surrounding the emitter and providing an electrical connection.Type: ApplicationFiled: May 3, 2013Publication date: July 16, 2015Applicant: Proxeon Biosystems A/SInventor: Ole Vorm
-
Publication number: 20140338430Abstract: An automated system for handling components of a chromatographic system, comprising: one or more trap columns each having sorbent material therein; a robotic system for moving a trap column from a storage position to an operating position where the trap column is connected in a liquid pathway along which solvent is flowed in operation to a liquid chromatography (LC) column; and an optical sensor for sensing one or more parameters of the trap column. Sensed parameters can include: a presence or absence of a trap column in the operating position, a position or orientation of the trap column, a fluid level in the trap column, the presence and position of a sorbent material in the trap column, the condition of the trap column and/or whether the trap column is new or used.Type: ApplicationFiled: October 31, 2013Publication date: November 20, 2014Applicant: Proxeon Biosystems A/SInventor: Soeren THEODORSEN
-
Patent number: 8613216Abstract: There is provided a method for thermally focusing the elution times of compounds of a liquid chromatography system comprising a pre-column and a separation column as well as to provide a liquid chromatography system, wherein the chromatographic separation of a mixture of substances is optimized.Type: GrantFiled: November 12, 2009Date of Patent: December 24, 2013Assignee: Proxeon Biosystems A/SInventor: Ole Vorm
-
Patent number: 8074494Abstract: The invention provided is a split-free nano-liter flow liquid chromatography system comprising at least a first and a second chromatographic column connected in series, wherein an autosampler is provided and programmed to inject samples and eluent solutions of increasing eluent concentration for gradually eluting analytes from the first column into the second column (without adversely affecting separation in the second column), said solutions segmented from the mobile phase of the liquid chromatography system by air plugs.Type: GrantFiled: November 13, 2008Date of Patent: December 13, 2011Assignee: Proxeon Biosystems A/SInventors: Ole Vorm, Michael Barrett Andersen, Ole Tang Sørensen, Søren Theodorsen
-
Publication number: 20110005304Abstract: A method for controlling the flow of liquid in a high performance liquid chromatography apparatus. The method includes operating a pump, measuring the liquid pressure downstream of the pump, measuring the liquid flow rate downstream of the pump, and controlling the operation of the pump. In the method, it is automatically determined whether the pump is controlled to achieve a desired pressure or controlled to achieve a desired flow rate. Fuzzy logic can be applied in the method to determine the switch between the control modes.Type: ApplicationFiled: January 22, 2009Publication date: January 13, 2011Applicant: Proxeon Biosystems A/SInventor: Ole Vorm
-
Publication number: 20090145203Abstract: The invention provided is a split-free nano-liter flow liquid chromatography system comprising at least a first and a second chromatographic column connected in series, wherein an autosampler is provided and programmed to inject samples and eluent solutions of increasing eluent concentration for gradually eluting analytes from the first column into the second column (without adversely affecting separation in the second column), said solutions segmented from the mobile phase of the liquid chromatography system by air plugs.Type: ApplicationFiled: November 13, 2008Publication date: June 11, 2009Applicant: Proxeon Biosystems A/SInventors: Ole Vorm, Michael Barrett Andersen, Ole Tang Sorensen, Soren Theodorsen