Abstract: The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target proteins; i.e. via degradation of a target protein/target proteins by the cullin-RING ubiquitin ligase (CRL). Such target protein/target proteins may be proteins involved in diseases, like cancer, metabolic disorder, infectious disease and/or neurological disorder. The invention further relates to a method for identifying/obtaining and/or testing a compound able to induce ubiquitination of a target protein/target proteins. The invention also relates to the compounds and composition for use as medicaments as well as pharmaceutical compositions comprising these compounds. Particularly, the compounds of the present invention may degrade proteins associated with cancer, metabolic disorder, infectious disease and/or neurological disorder.

Abstract: The present invention relates to a method for obtaining an intron-tagged pool of cells representing and/or comprising tagged introns. Furthermore, the present invention relates to a pool of cells that may be obtainable by said method, in particular an intron-tagged pool of cells. The present invention furthermore provides for a method for automated recognition of the identity of the tagged intron(s) comprised in the genome of an intron-tagged cell within an intron-tagged pool of cells and a method for assessing the effect of a perturbation on the proteome and/or gene expression levels of an intron-tagged cell within an intron-tagged pool of cells.