Abstract: The present disclosure relates to a supramolecular preparation of retinol and derivatives thereof and a preparation method therefor, wherein the supramolecular preparation consists of following components in percentage by mass: 3.00-25.0% of retinol and derivatives thereof, 36.5-91.0% of hydroxypropyl ?-cyclodextrin, 4.00-32.0% of hydroxypropyl methylcellulose stearoxy ether, and 2.00-8.0% of PEG/PPG/polybutylene glycol-8/5/3 glycerin, wherein the mass ratio of the PEG/PPG/polybutylene glycol-8/5/3 glycerin to the hydroxypropyl methylcellulose stearoxy ether is 1:2-4. The supramolecular preparation of retinol and derivatives thereof obtained in the present disclosure has the advantages such as good stability, high solubility, low irritation, and good anti-wrinkle effect.

Abstract: The present disclosure relates to a supramolecular preparation of retinol and derivatives thereof and a preparation method therefor, wherein the supramolecular preparation consists of following components in percentage by mass: 3.00-25.0% of retinol and derivatives thereof, 36.5-91.0% of hydroxypropyl ?-cyclodextrin, 4.00-32.0% of hydroxypropyl methylcellulose stearoxy ether, and 2.00-8.0% of PEG/PPG/polybutylene glycol-8/5/3 glycerin, wherein the mass ratio of the PEG/PPG/polybutylene glycol-8/5/3 glycerin to the hydroxypropyl methylcellulose stearoxy ether is 1:2-4. The supramolecular preparation of retinol and derivatives thereof obtained in the present disclosure has the advantages such as good stability, high solubility, low irritation, and good anti-wrinkle effect.