Patents Assigned to PRP, Inc.
  • Reconstituted platelet membrane vesicles
    Patent number: 5844098
    Abstract: A reconstituted platelet membrane vesicle preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from either synthetic sources or from mammalian platelet membranes. The product may be used for transfusions or may be topically applied. Methods for forming the vesicles and products for storing and dispensing the vesicles also are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 1, 1998
    Assignee: PRP, Inc.
    Inventors: Francis C. Chao, Frank Huayueh Liang
  • P.sup.1, P.sup.4 -dithio-P.sup.2 -P.sup.3 -monochloromethylene 5', 5'"-diadenosine P.sup.1, P.sup.4 -tetraphosphate as antithrombotic agent
    Patent number: 5681823
    Abstract: A novel composition, P.sup.1, P.sup.4 -dithio-P.sup.2, P.sup.3 -monochloromethylene 5', 5'"-diadenosine P.sup.1, P.sup.4 -tetraphosphate, is disclosed. The composition is useful as a therapeutic agent for prevention of thrombosis and for modulating a thrombolytic effect in a mammal.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: October 28, 1997
    Assignee: PRP Inc.
    Inventors: Byung K. Kim, Paul C. Zamecnik
  • Reconstituted platelet membrane vesicles
    Patent number: 5578565
    Abstract: A reconstituted platelet membrane vesicle preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from either synthetic sources or from mammalian platelet membranes. The product may be used for transfusions or may be topically applied. Methods for forming the vesicles and products for storing and dispensing the vesicles also are provided.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: November 26, 1996
    Assignee: PRP, Inc.
    Inventors: Francis C. Chao, Frank H. Liang
  • Inhibition of platelet binding
    Patent number: 5462752
    Abstract: Methods for inhibiting the attachment of platelets to a site of an injury are provided. The methods involve administering to a subject that has sustained an injury an effective amount of a platelet binding-site agent. Preferred platelet binding-site agents are platelets that are substantially free of platelet substances contained in lysosomes, dense granules or alpha granules.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: October 31, 1995
    Assignee: PRP, Inc.
    Inventors: Francis C. Chao, deceased, Michael S. Chao, heir, Mark S. Chao, heir, Lorraine S. Chao, heir
  • Therapeutic composition of micellar structures capable of promoting hemotasis
    Patent number: 5428008
    Abstract: A reconstituted platelet membrane vesicle or micellar structure preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from either synthetic sources or from mammalian platelet membranes. The product may be used for transfusions or may be topically applied. Methods for forming the vesicles or micellar structures and products for storing and dispensing the vesicles or micellar structures also are disclosed.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: June 27, 1995
    Assignee: PRP, Inc.
    Inventors: Francis C. Chao, Frank H. Liang
  • Platelet membrane microparticles
    Patent number: 5332578
    Abstract: A heat-treated, viral-inactivated platelet membrane microparticle product is provided. The microparticles may be prepared from outdated mammalian platelets. The microparticle product contains isolated platelet membrane fragments that are free of alloantigens and GP IIb/IIIa complexes further, the product may be used as a pharmaceutical preparation in transfusions.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: July 26, 1994
    Assignee: PRP, Inc.
    Inventor: Francis Chao
  • Platelet membrane microvesicles
    Patent number: 5185160
    Abstract: A heat-treated, viral-inactivated platelet membrane microparticle fraction is provided. The microparticles may be prepared from outdated platelets. The microparticle fraction is substantially free of platelet ghosts and may be used as a pharmaceutical preparation in transfusions.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: February 9, 1993
    Assignee: PRP, Inc.
    Inventor: Francis C. Chao