Patents Assigned to PTM BIO LLC
  • Reagents and methods for detecting protein lysine 3-hydroxybutyrylation
    Patent number: 11385240
    Abstract: The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 12, 2022
    Assignee: PTM BIO LLC
    Inventors: Yingming Zhao, Zhongyu Xie
  • Reagents and methods for detecting protein crotonylation
    Patent number: 10908169
    Abstract: The invention provides an isolated peptide comprising a crotonylation site, a Kcr-specific affinity reagent that specifically binds to the peptide, and a method for detecting protein crotonylation in a sample using the reagent.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: February 2, 2021
    Assignee: PTM BIO LLC
    Inventors: Yingming Zhao, Jeong Soo Yang, Hao Luo, Zhongyi Cheng
  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 3-HYDROXYBUTYRYLATION
    Publication number: 20190331695
    Abstract: The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 31, 2019
    Applicant: PTM BIO LLC
    Inventors: Yingming ZHAO, Zhongyu XIE
  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 2-HYDROXYISOBUTYRYLATION
    Publication number: 20190145986
    Abstract: The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 16, 2019
    Applicant: PTM BIO LLC
    Inventors: Yingming ZHAO, Lunzhi DAI
  • REAGENTS AND METHODS FOR DETECTING PROTEIN CROTONYLATION
    Publication number: 20190137512
    Abstract: The invention provides an isolated peptide comprising a crotonylation site, a Kcr-specific affinity reagent that specifically binds to the peptide, and a method for detecting protein crotonylation in a sample using the reagent.
    Type: Application
    Filed: January 16, 2019
    Publication date: May 9, 2019
    Applicant: PTM BIO LLC
    Inventors: Yingming Zhao, Jeong Soo Yang, Hao Luo, Zhongyi Cheng
  • Agent and method for identifying lysine crotonylation in proteins
    Patent number: 9625467
    Abstract: A method and related agent for detecting novel post-translational modification. This novel post-translational modification is in the form of crotonylation of lysine residues in proteins. The method includes the steps of (a) preparing a mixture of polypeptides from a protein sample; (b) separating the polypeptides by molecular weight; (c) contacting the separated polypeptides with a binding affinity reagent which binds specifically to a polypeptide containing a crotonyllysine residue; and (d) detecting presence of a binding complex between the affinity reagent and one or more of the polypeptides. An example of the binding agent is an antibody, which may be prepared from animal serums, or is a monoclonal antibody or single-chain variable fragment.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: April 18, 2017
    Assignee: PTM BIO LLC
    Inventor: Yingming Zhao