Patents Assigned to PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC., a New York Corporation
  • Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
    Publication number: 20030162210
    Abstract: A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable segment. The constant segment of the immobilized oligonucleotides can be made complementary to the ends of strands obtained by digesting a double-stranded nucleic acid with a restriction enzyme and restoring the restriction sites, thereby permitting the sorting of strands according to their variable sequences adjacent to their constant terminal restored restriction sites.
    Type: Application
    Filed: December 31, 2002
    Publication date: August 28, 2003
    Applicant: PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC., a New York Corporation
    Inventors: Alexander B. Chetverin, Fred Russell Kramer
  • HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies
    Publication number: 20030105282
    Abstract: The invention features a protein which includes a gp120 V1/V2 domain of an HIV-1 strain and not a gp120 V3 domain of an HIV-1 strain, which protein does not substantially bind CD4. The gp120 V1/V2 domain of the protein displays an epitope which is recognized by an antibody which neutralizes at least one HIV-1 primary isolate with a ND90 of less than 100 &mgr;g/ml.
    Type: Application
    Filed: January 2, 2002
    Publication date: June 5, 2003
    Applicant: The Public Health Research Institute of the City of New York, Inc., a New York corporation
    Inventor: Abraham Pinter