Abstract: A method of producing a nicotine medicament for use in an inhaler comprises combining a nicotine formulation, a sugar and a liquid carrier including water to produce a flowable mixture and drying the flowable mixture at conditions to produce particles of the nicotine medicament suitable for delivery to the alveoli and lower airways of the person. Also disclosed is a nicotine medicament made by the method. The nicotine composition produced by this method is a composite particle suitable for tobacco replacement or withdrawal therapy.

Abstract: A method of producing a nicotine medicament for use in an inhaler comprises combining a nicotine formulation, a sugar and a liquid carrier including water to produce a flowable mixture and drying the flowable mixture at conditions to produce particles of the nicotine medicament suitable for delivery to the alveoli and lower airways of the person. Also disclosed is a nicotine medicament made by the method. The nicotine composition produced by this method is a composite particle suitable for tobacco replacement or withdrawal therapy.

Abstract: A packaging system includes a container having a closure therefore. A vacuum or gas pressure is provided within the container during the packaging process. The container also includes an aperture and a sealing member for the aperture, the latter being designed so that an audible puff of air can be noticed by the consumer when the sealing member is removed from the aperture. The system of the present invention may include a separate package sealing lid or a child-proof lid selected from a variety of such lids known to the art. Unlike prior art packaging systems which claim to be "tamper-proof," the system of the present invention provides an audible warning sound which will forewarn the consumer if package tampering or a package manufacturing failure has occurred. Inner liner or double container systems using a similar aperture and sealing system are also disclosed.