Abstract: Ultra-low frequency (ULF) tactile stimuli, generated by an electro-mechanical actuator, have a spectrum of biological effects. These frequencies are herewith defined as 2 Hz or lower and may comprise stimulus frequencies as low as 0.1 Hz, or one cycle per ten seconds. The ULF generator can be paired with at least one sensor that is configured to monitor a physiological property of the user. A controller is in communication with the at least one electro-mechanical actuator and the at least one sensor and is configured to control operation of the at least one electro-mechanical actuator, in at least a first operating mode, based on measurements of the at least one sensor.