Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Application
Filed:
February 18, 2013
Publication date:
September 11, 2014
Applicants:
VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
Inventors:
ALLAN SY LAU, LAI HUNG CINDY YANG, CHI CHUNG STANLEY CHIK, CHUN BONG JAMES LI
Abstract: A method for isolating cimiracemate A from a Cimicifuga species is disclosed, comprising the steps of a) providing a sufficient quantity of raw materials from the Cimicifuga species, b) mixing the raw materials from the Cimicifuga species with an aqueous polar solvent at a temperature of about 20° C. to about 28° C. to obtain a solvent extract comprising cimiracemate A, and c) isolating cimiracemate A from the solvent extract.
Type:
Grant
Filed:
June 21, 2010
Date of Patent:
January 21, 2014
Assignees:
Purapharm Company Limited, Versitech Limited
Abstract: The subject invention provides Coriolus versicolor extracts, pharmaceutical compositions comprising the Coriolus versicolor extracts, methods of preparation, and therapeutic uses thereof. Advantageously, the subject Coriolus versicolor extract has immunomodulatory, anti-tumor, anti-microbial, and antiviral effects. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells. In certain preferred embodiments, the subject invention can be used to treat glioblastoma multiforme, nasopharyngeal carcinoma, breast carcinoma, lung carcinoma, prostate cancer, and colon carcinoma, as well as bacterial, viral, fungal, protozoan, and/or other microbial infection.
Type:
Application
Filed:
October 6, 2011
Publication date:
January 16, 2014
Applicants:
VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
Abstract: The present invention pertains to Cimiracemate A and related compounds that are useful as inhibitors of 5-lipoxygenase (5-1. OX) activity and various proinflammatory mediators such as lipoxins, leukotrienes (e.g., LTA4, LTB4, LTC4, LTD4, and LTE4), prostaglandins, and thromboxanes. The present invention also provides therapeutic methods and compositions for treatment of inflammation and inflammatory conditions, including allergenic reactions, diseases associated with cell proliferation, neoangiogenesis, and cardiovascular diseases.
Type:
Application
Filed:
July 29, 2011
Publication date:
December 5, 2013
Applicants:
VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
Abstract: The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor. In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor, as well as 9-KODE methyl ester and related compounds. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells.
Type:
Application
Filed:
March 14, 2013
Publication date:
October 17, 2013
Applicants:
VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
Inventors:
ALLAN SIK YIN LAU, LAI HUNG CINDY YANG, STANLEY CHI CHUNG CHIK
Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Application
Filed:
March 8, 2013
Publication date:
September 12, 2013
Applicants:
VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
Inventors:
ALLAN SIK YIN LAU, LAI HUNG CINDY YANG, STANLEY CHI CHUNG CHIK
Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Grant
Filed:
December 28, 2009
Date of Patent:
February 19, 2013
Assignees:
PuraPharm Company Limited, Versitech Limited
Inventors:
Allan Sy Lau, Lai Hung Cindy Yang, Chi Chung Stanley Chik, Chun Bong James Li