Patents Assigned to PURDUE RESEARCH FOUNDATION (PRF)
  • Publication number: 20260267944
    Abstract: A system is provided for identifying a source language model that generated an input text. The system may tokenize the input text to generate a token sequence and execute a surrogate neural language model on the token sequence to obtain output logits representing internal inference states of the surrogate neural language model. The system may generate context loss sequences by computing cross-entropy losses between output logits and adjacent tokens within a fixed context window. From the context loss sequences, the system may extract a multi-dimensional inference pattern tensor that includes independent pattern features derived from individual context loss sequences and correlated pattern features derived from pairwise relationships between context loss sequences. A classifier model is executed based on the multi-dimensional inference pattern tensor to identify an originating language model associated with the input text.
    Type: Application
    Filed: March 4, 2026
    Publication date: September 10, 2026
    Applicant: Purdue Research Foundation
    Inventors: Xiangyu Zhang, Hanxi Guo, Zhuo Zhang
  • Patent number: 12728136
    Abstract: The present disclosure generally relates to a process for manufacturing liposomes containing polymyxin and quinolone as a treatment for bacterial infections. In particular, the present invention utilizes an anionic lipid as an essential component of a liposome for efficient encapsulation of polymyxin and quinolone, which affords a stable more efficient pharmaceutical composition for the treatment of a bacterial infection, especially infections of the lungs. Pharmaceutical compositions and methods of treatment are within the scope of this invention.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: September 8, 2026
    Assignee: Purdue Research Foundation
    Inventors: Qi Zhou, Shaoning Wang
  • Patent number: 12729696
    Abstract: The casing treatment system includes a compressor having an injection port, an extraction portion, a recirculation channel. It is also contemplated for the casing treatment system to include a plurality of injection ports, a plurality of extraction ports, and/or a plurality of recirculation channels. The casing treatment system is based on using the differences in the flow field at peak efficiency and near stall to “turn on” the recirculation at near stall operation to extend the stall margin, and to “turn off” the recirculation at peak efficiency operation to minimize impact to efficiency.
    Type: Grant
    Filed: March 21, 2024
    Date of Patent: September 8, 2026
    Assignee: Purdue Research Foundation
    Inventors: Nicole Leanne Key, William Joseph Brown, Andrew Curtis Cusator, Yu Ning Dai
  • Publication number: 20260259165
    Abstract: A pH sensor for determining food freshness may include a substrate and a working tag on the substrate. The working tag may have a first resonant frequency. A reference tag may also be on the substrate. The reference tag may have a second resonant frequency. The pH sensor may further include a first layer in contact with a portion of the working tag and not the second tag. The first layer may be water soluble. The pH sensor may include a second layer positioned on top of the first layer, the second layer configured to dissolve when exposed to an environment having a pH level higher than a threshold pH. Dissolution of the second layer may cause a change in the resonant frequency of the working tag.
    Type: Application
    Filed: March 11, 2024
    Publication date: September 3, 2026
    Applicant: Purdue Research Foundation
    Inventors: Rahim Rahimi, Sarath Gopalakrishnan, Jose Waimin
  • Publication number: 20260262365
    Abstract: An intelligent vision system, including a training array of photonic-organic electrochemical transistor (POECT) devices, each including a substrate, three terminals including a gate, a drain, and a source disposed over the substrate, wherein space between the drain and the source forms a channel, an electrolyte in fluid and electrical communication with the gate and the channel, wherein the channel is formed of a photoactive layer composed of donor-acceptor bulk heterojunction interfaces, each POECT device of the training array provides a memory feature when exposed to light, wherein an image to be recognized is imprinted on the training array by exposing the training array with light corresponding with the image to be recognized, and a discriminator configured to compare the training array with a test model associated with an image to be tested against the image to be recognized, wherein the discriminator signals a match or a mismatch based on a comparison.
    Type: Application
    Filed: March 7, 2024
    Publication date: September 3, 2026
    Applicant: Purdue Research Foundation
    Inventors: Ke CHEN, Jianguo MEI
  • Patent number: 12721898
    Abstract: A compound of formula Fa-L-Ia (A) or Fa-Ia (B), wherein Fa is a fibroblast activation protein alpha (FAP?) targeting moiety, L is a linker, and Ia is an inhibitor of a signaling pathway necessary for fibrosis in cancer-associated fibroblasts (CAFs); a pharmaceutical composition comprising same; and methods for treating a tumor, a cancer or a fibrotic disease in a subject.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 1, 2026
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Spencer D. Lindeman, Ramesh Mukkamala
  • Patent number: 12723887
    Abstract: A wearable device worn by a user is disclosed which includes a plurality of input device interfaces each configured to receive input from a sensor coupled to a user, a controller configured to generate a two-dimensional map of the user's three-dimensional space based on the received inputs, and a plurality of haptic feedback devices disposed on the wearable device, wherein the controller is configured to selectively activate each of the plurality of haptic feedback devices to signal the user's position in the three-dimensional space based on the generated two-dimensional map as the user moves in the three-dimensional space.
    Type: Grant
    Filed: December 6, 2023
    Date of Patent: September 1, 2026
    Assignee: Purdue Research Foundation
    Inventors: Ethan M. Brown, Eric P. O'Keefe, Fernando Vega, Shyam K. Reddy, Ivan Malov
  • Patent number: 12724281
    Abstract: A metalenslet beam homogenizer offers an alternative to classical beam homogenization techniques by leveraging flat optical metasurfaces. The metalenslet beam homogenizer would be beneficial, for example, for high power laser applications, such as laser material processing, digital projection, optical lithography, and additive manufacturing in which it is necessary to expose a certain area on a workpiece to a well-defined amount of optical radiation. The metalenslet beam homogenizer provides benefits by enhancing the beam homogenization quality, reducing size and complexity, and lowering optical power loss. It does so by using nanophotonic metasurface lenses and offers higher homogenization quality by mitigating the impact of diffraction and reducing the size of the optical system by combining the functionality of multiple optical elements into fewer devices.
    Type: Grant
    Filed: January 3, 2024
    Date of Patent: September 1, 2026
    Assignees: ZS Systems LLC, Purdue Research Foundation
    Inventors: Sergey Zakharov, Alexander Kildishev, Omer Yesilyurt
  • Patent number: 12723603
    Abstract: A valve arrangement includes a plurality of hydraulic rail ports each configured to be coupled to a pressure rail, a plurality of hydraulic chamber ports each configured to be coupled to a chamber of one or more actuators, a plurality of proportional valves each corresponding to one of the plurality of hydraulic chamber ports, one or more sets of on-off valves and check valves coupling two or more hydraulic rail ports to each of the supply sides of each of the plurality of proportional valves, and one or more sets of on-off valves and check valves coupling two or more hydraulic rail ports to each of the return sides of each of the plurality of proportional valves, wherein electively operating each of the on-off valves and the proportional valves provides selective pressure or flow to each one of the plurality of hydraulic chamber ports.
    Type: Grant
    Filed: May 2, 2025
    Date of Patent: September 1, 2026
    Assignees: Purdue Research Foundation, Wipro Enterprises Pvt Ltd
    Inventors: Mateus Bertolin, Xiaofan Guo, Andrea Vacca, Jan Nilsson
  • Publication number: 20260251610
    Abstract: A method of measuring ultra-low concentration of a target analyte in a host fluid includes placing a droplet by a micropipette having an ejection tip, positioned by a micro-positioner, configured to position the ejection tip atop a first electrode in electrochemical contact with an electrolyte disposed in a first vessel, such that a droplet having an initial radius comprising of a target analyte in a host fluid can be deposited atop the first electrode, iteratively applying a potential to the first electrode and measuring electrical current between the first electrode and a second electrode in electrochemical contact with the electrolyte based on a predetermined voltage sweep rate, obtaining current vs. voltage curves for each voltameter iteration, identifying redox or oxidation peaks for each voltameter iteration based on a predetermined criterion, and determining target analyte concentration based on the identified redox or oxidation peaks.
    Type: Application
    Filed: December 23, 2025
    Publication date: August 27, 2026
    Applicant: Purdue Research Foundation
    Inventors: Jeffrey Edward Dick, Ashutosh Rana, Christophe Jacques Renault
  • Patent number: 12715111
    Abstract: The robot control system configured to control a robot includes a gantry frame having an x-axis guide, a y-axis guide, a first arm, and a second arm. The y-axis guide is coupled to the x-axis guide. The y-axis guide is selectively movable along an x-axis of the x-axis guide. Each of the first arm and the second arm are coupled to the y-axis guide. Each of the first arm and the second arm are independently movable along a y-axis of the y-axis guide. The first arm and/or the second arm are independently movable along a z-axis. A magnet device is coupled to the first arm. An imaging device is coupled to the second arm.
    Type: Grant
    Filed: September 26, 2024
    Date of Patent: August 25, 2026
    Assignee: Purdue Research Foundation
    Inventor: David John Cappelleri
  • Patent number: 12717177
    Abstract: The present invention relates to an electrically tunable photonic resonator device for a component having a fast and flat actuation response. The photonic resonator device includes at least one optical waveguide with an optical interface for coupling in laser light. The photonic resonator device includes at least one optical resonator including a waveguide made of an optical resonator material. A laser light coupled via the optical waveguide is coupled into at least one optical resonator. The photonic resonator device includes at least one piezo actuator to apply mechanical stress onto the optical resonator. The optical resonator, the piezo actuator, and the optical waveguide are monolithically integrated on a common substrate of the photonic resonator device. The photonic resonator device includes a mechanical mode suppression means configured to attenuate one or more mechanical modes of oscillation caused by an AC operation of the piezo actuator.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: August 25, 2026
    Assignees: Ecole Polytechnique Federale De Lausanne (EPFL), Purdue Research Foundation
    Inventors: Tobias Kippenberg, Sunil Bhave, Hao Tian, Johann Riemensberger, Grigorii Likhachev, Anat Siddharth
  • Patent number: 12714976
    Abstract: A fluidized bed granulation (FBG) system includes a pre-wetting subsystem, wherein feedstock is pre-wet to a predetermined % value, a fluidization chamber (FC), an inlet coupled to the FC, a plenum coupled to the FC by a distributor plate having slots through which a fluidization gas is passed to the FC at a velocity and a direction, an outlet compartment coupled to the FC by a termination plate having one or more filter bags, a liquid binder system adapted to introduce a liquid binder into the FC, and an outlet configured to eject granulated product, and a plurality of sensors adapted to inform a processor executing instructions maintained on a non-transitory memory, wherein the processor using a mass, energy, and fluidization balance model is adapted to optimize the FBG system to provide the granulated product having an optimized geometric mean and geometric standard deviation between about 2.0 and about 1.0.
    Type: Grant
    Filed: September 26, 2024
    Date of Patent: August 25, 2026
    Assignees: Purdue Research Foundation, Eli Lilly and Company
    Inventors: Paul R. Mort, Line Koleilat, Jonathan Wade, Joshua Hanson
  • Patent number: 12708299
    Abstract: A direct electron transfer amperometric biosensor fabricated using direct write printing technology for in vivo electrochemical monitoring, such as monitoring of neurotransmitters and other biomarkers, e.g., in traumatic spinal cord injury. The biosensor is fabricated by immobilizing glutamate oxidase on nanocomposite electrodes made of platinum nanoparticles, multiwall carbon nanotubes and a conductive polymer on a flexible substrate.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: August 18, 2026
    Assignee: Purdue Research Foundation
    Inventors: Hyowon Lee, Tran N.H. Nguyen
  • Publication number: 20260233310
    Abstract: A method of mitigating crack formation in an article produced by additive manufacturing process is disclosed. The method utilizes Selective laser melting (SLM). The method contains the steps of utilizing a selective leaser melting (SLM) apparatus to produce a first layer of particles of a selected material on a substrate and melting and solidifying a first group of selected areas of the first layer of particles, wherein the melting and the solidification results in a pre-determined structure of the selected material; repeating utilization of SLM apparatus to produce second and subsequent layers as needed to produce layers of desired configurations to result in a predetermined scaffolding structure; and utilizing a selective leaser melting (SLM) apparatus to produce an article of specified thickness and shape on top of and in contact with the scaffolding structure. An article made by the method of this disclosure is described.
    Type: Application
    Filed: December 19, 2024
    Publication date: August 13, 2026
    Applicant: Purdue Research Foundation
    Inventors: Xinghang Zhang, Haiyan Wang, Benjamin Thomas Stegman, Anyu Shang
  • Publication number: 20260235600
    Abstract: A method for determining absolute thickness of bacterial colonies include transferring one or more bacterial colonies to an infrared (IR) transparent substrate, shining visible light; polarizing the shone visible light, thus polarizing the visible light at a predetermined linear polarization, converting the linearly polarized light to circularly polarized light, combining IR light from a second light source with the linearly polarized light, focusing the combination of IR light and the linearly polarized light by an objective onto the IR transparent substrate with the one more bacterial colonies disposed thereon, back-reflecting probe beam light from the one or more bacterial colonies, polarizing the back-reflected probe beam light, focusing the polarized back-reflected probe beam light by a lens, receiving the polarized back-reflected probe beam light by a detector, performing optical photothermal mid-infrared (O-PTIR) measurements on the detected light while varying IR and back-reflected probe beam light po
    Type: Application
    Filed: January 22, 2026
    Publication date: August 13, 2026
    Applicant: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Caitlin Elizabeth Dunlap, Alexander James Higgins
  • Patent number: 12702338
    Abstract: A wearable device may include a sensor. The sensor may include a flexible fabric, a conjugated polymer coating deposited on the fabric via vapor-phase oxidative chemical vapor deposition (oCVD), and a plurality of electrodes in coupled to the conjugated polymer coating. The wearable device may further include a processor communicatively coupled to the electrodes. The processor may measure an electrical property across the electrodes, determine a physiological event based on the measured electrical property, and output measurement information corresponding the physiological event.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: August 11, 2026
    Assignee: Purdue Research Foundation
    Inventors: Sunghwan Lee, Hyeonghun Kim, Michael Vincent Clevenger, Jung Joo Sohn
  • Patent number: 12698246
    Abstract: The disclosure provides a method of dehydrogenating hydrocarbons, such as C2 or C3 hydrocarbons, selectively and efficiently, to provide the corresponding alkylenes. The method is based on a Pt nanolayer catalyst over MXene (Pt/MXene) that shows resistance to coke deposition. The dehydrogenation conditions developed provided about 22% propane conversion and over 90% selectivity toward the desired propylene product, and the catalyst was stable for a 24-hour continuous run. The byproducts were ethane, ethylene, and methane, and only trace amounts of coke deposition over the catalyst were detected. Similar dehydrogenation conditions provided about 18% ethane conversion and over 90% selectivity toward the desired ethylene product. A mass balance of greater than 96% was achieved in each case.
    Type: Grant
    Filed: October 16, 2023
    Date of Patent: August 4, 2026
    Assignees: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC., PURDUE RESEARCH FOUNDATION
    Inventors: Yue Wu, Zhe Li, Fan Yang, Yang Xiao
  • Patent number: 12699068
    Abstract: The electrochemical sensor system includes a capillary and a conductive wire at least partially disposed within the capillary. The wire is provided as a plurality of wires, such as a pair wires. The plurality of wires is disposed substantially parallel within the capillary. The wire extends from a first terminal end of the capillary to a second terminal end of the capillary. Where the wire is provided as a plurality of wires, the capillary includes a capillary wall separating the plurality of wires. The first terminal end of the capillary includes an electrode surface where the wire is disposed therethrough and is exposed, thus forming an electrode. The exposed wire is configured to form a liquid-air interface where a droplet is disposed on the exposed wire. The wire extending from the second terminal end of the capillary is coupled to a processor configured to perform the electrochemical analysis.
    Type: Grant
    Filed: March 15, 2024
    Date of Patent: August 4, 2026
    Assignee: Purdue Research Foundation
    Inventors: Philip James Kauffmann, Jeffery Edward Dick
  • Patent number: 12699085
    Abstract: A ?PAD may include a paper-based substrate and a non-polar material printed on a surface of the substrate such that a portion the surface is exposed. The exposed portion may include a receiving area, a plurality of test areas, and a plurality of channels disposed between the receiving area and the test areas. The ?PAD may further include colorimetric sensors respectively positioned in the test areas. The channel regions may be configured to receive an analyte solution from the receiving area and direct the analyte solution to the colorimetric sensors. A system may perform image processing on captured images of the ?PAD to provide multiplexed analysis of analyte solutions applied to the ?PAD.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 4, 2026
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Lia Antoaneta Stanciu-Gregory, Jan P. Allebach, George Tsu-Chih Chiu, Lixby S. Diaz, Min Zhao