Abstract: A collagen-based therapeutic delivery device includes an insoluble synthetic collagen-fibril matrix comprising a polymerization product of soluble oligomeric collagen or a polymerization product of a mixture of soluble oligomeric collagen with one or more type of non-oligomeric soluble collagen molecules, such as, for example, soluble telocollagen and/or soluble atelocollagen, and an active agent dispersed throughout the collagen-fibril matrix or within a portion of the collagen-fibril matrix. A pre-matrix composition includes an aqueous solution including soluble collagen-fibril building blocks and an active agent in the aqueous solution. The soluble collagen-fibril building blocks include soluble oligomeric collagen or a mixture of soluble oligomeric collagen with non-oligomeric soluble collagen molecules. The building blocks are operable to self-assemble into a macromolecular synthetic collagen-fibril matrix in the absence of an exogenous cross-linking agent.

Abstract: Systems and methods for generating spectrally compressed photons from broadband emitted photon pulses. The system can include an input coupling having a first coupling ratio an output coupling having a second coupling ratio. The first coupling ratio is configurable and the second coupling ratio is fixed. A cavity can be connected to the input coupling and the output coupling. A controller in electrical communication with the coupling device can be configured to change the first coupling ratio of the input coupling.

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

Abstract: A novel catalyst composition and its use in the dehydrogenation of alkanes to olefins. The catalyst comprises a Group VIII noble metal and a metal selected from the group consisting of manganese, vanadium, chromium, titanium, and combinations thereof, on a support. The Group VIII noble metal can be platinum, palladium, osmium, rhodium, rubidium, iridium, and combinations thereof. The support can be silicon dioxide, titanium dioxide, aluminum oxide, silica-alumina, cerium dioxide, zirconium dioxide, magnesium oxide, metal modified silica, silica-pillared clays, silica-pillared micas, metal oxide modified silica-pillared mica, silica-pillared tetrasilicic mica, silica-pillared taeniolite, zeolite, molecular sieve, and combinations thereof. The catalyst composition is an active and selective catalyst for the catalytic dehydrogenation of alkanes to olefins.

Abstract: A frequency agile tunable self-injection locking laser system being formed by a laser device coupled to at least one optical resonator and method and controller therefor are disclosed. A diode current and an optical resonator are controllable. A self-injection locking range is selected and the self-injection locking range corresponds an optical feedback phase for back-reflected light from the optical resonator into the laser device. A diode current is set and a maximum tuning range of the actuation voltage in which self-injection locking is maintained is determined. The laser system is operated with actuation voltages in a range depending on the determined tuning range.

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract: The present invention relates to an electrically tunable photonic resonator device for a component having a fast and flat actuation response. The photonic resonator device includes at least one optical waveguide with an optical interface for coupling in laser light. The photonic resonator device includes at least one optical resonator including a waveguide made of an optical resonator material. A laser light coupled via the optical waveguide is coupled into at least one optical resonator. The photonic resonator device includes at least one piezo actuator to apply mechanical stress onto the optical resonator. The optical resonator, the piezo actuator, and the optical waveguide are monolithically integrated on a common substrate of the photonic resonator device. The photonic resonator device includes a mechanical mode suppression means configured to attenuate one or more mechanical modes of oscillation caused by an AC operation of the piezo actuator.

Abstract: The present disclosure provides a transparent alumina-based plate, and a hot-pressing method to make the transparent alumina-based plate from platelet alumina. Alumina powder with a platelet morphology was hot-pressed to transparency with pre-load pressures of about 0-8 MPa, maximum temperatures of about 1750-1825° C., maximum pressures of about 2.5-80 MPa, and isothermal hold times of 1-7 hours. A novel alumina-based plate has been prepared, wherein the plate has a thickness of 2-5 mm, an in-line transmission of at least 60-75% for a light with a wavelength range of 645-2500 nm, an in-line transmission variance of <15% over the wavelength range of 645-2500 nm, and a relative density of 99.00-99.95%.

Abstract: A novel catalyst composition and its use in the dehydrogenation of alkanes to olefins. The catalyst comprises a Group VIII noble metal selected from the group consisting of nickel, iron, cobalt, and combinations thereof, and a metal selected from the group consisting of molybdenum, indium, phosphorous, zinc, and combinations thereof, on a support. The catalyst composition is an active and selective catalyst for the catalytic dehydrogenation of alkanes to olefins.

Abstract: Methods for measuring diffusion in a medium. One method includes dissolving a fluorescent sample in a medium, imaging the fluorescent sample with a patterned illumination Fluorescence Recovery After Photobleaching (FRAP) technique, and analyzing a set of microscope images of the photobleached dissolved fluorescent sample with the patterned illumination using a Fourier Transform (FT) FRAP technique.

Abstract: A sensor, comprising a deformable substrate, comprising a structural metamaterial in a first configuration; a plurality of raised structures disposed throughout the substrate, wherein the plurality of raised structures are invertible; a responsive material layer, wherein the responsive material layer is disposed on the plurality of raised structures and is configured to invert the plurality of raised structures in the presence of an external stimuli; and a plurality of second configurations of the deformable substrate that correspond to a plurality of inverted raised structures.

Abstract: Systems and processes for dehydrogenating one or more alkanes using electrically heated dehydrogenation reactors. The source of electric energy or power can be a power grid, solar panel, windmill, hydropower, nuclear power, fuel cell, gas turbines, steam turbines, portable generator or the like. The systems and processes provided herein result in a simpler dehydrogenation process which is particularly beneficial at a small scale and at remote locations, including the well site.

Abstract: Embodiments of the present disclosure are disclosed for enhancing resolution for nonlinear optical microscopy. Embodiments include pulse picking using a modulator, such as an acousto-optic modulator, that is optionally controlled by a function generator or a frequency divider. Some embodiments spatially overlap two laser beams prior to the modulator, and still additional embodiments include separating the 1st diffraction order of the modulated laser output of the acousto-optic modulator and directing the 1st diffraction order to a microscope. Some embodiments chirp a spatially overlapped laser beam with one pulse rate to a spatially overlapped laser beam with a higher pulse rate, while still additional embodiments utilize a coherent Raman scattering microscope.

Abstract: The disclosure provides a method of dehydrogenating hydrocarbons, such as C2 or C3 hydrocarbons, selectively and efficiently, to provide the corresponding alkylenes. The method is based on a Pt nanolayer catalyst over MXene (Pt/MXene) that shows resistance to coke deposition. The dehydrogenation conditions developed provided about 22% propane conversion and over 90% selectivity toward the desired propylene product, and the catalyst was stable for a 24-hour continuous run. The byproducts were ethane, ethylene, and methane, and only trace amounts of coke deposition over the catalyst were detected. Similar dehydrogenation conditions provided about 18% ethane conversion and over 90% selectivity toward the desired ethylene product. A mass balance of greater than 96% was achieved in each case.

Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

Abstract: Processes and systems for upgrading natural gas liquids. At least a portion of the natural gas liquid components in a shale gas stream can be dehydrogenated to their corresponding olefin derivatives prior to separating any methane from the liquids. Further processing subsequent to dehydrogenation could include various separations, oligomerizing olefins produced in the dehydrogenation step, recovering desired products, etc. The order of the processing steps subsequent to dehydrogenation could be adjusted in various cases.

Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.

Abstract: A cooling system that includes an expandable vapor chamber having a condenser side opposite an evaporator side, a condenser side wick coupled to a condenser side wall, an evaporator side wick coupled to an evaporator side wall, and a vapor core positioned between the evaporator side wick and the condenser side wick. The cooling system also includes a vapor pressure sensor communicatively coupled to a controller and a bellow actuator disposed in the vapor core and communicatively coupled to the controller. The bellow actuator is expandable based on a vapor pressure measurement of the vapor pressure sensor.

Abstract: Disclosed is a visual and spatial programming system for robot navigation and robot-IoT task authoring. Programmable mobile robots serve as binding agents to link stationary IoT devices and perform collaborative tasks. Three key elements of robot task planning (human-robot-IoT) are coherently connected with one single smartphone device. Users can perform visual task authoring in an analogous manner to the real tasks that they would like the robot to perform with using an augmented reality interface. The mobile device mediates interactions between the user, robot(s), and IoT device-oriented tasks, guiding the path planning execution with Simultaneous Localization and Mapping (SLAM) to enable robust room-scale navigation and interactive task authoring.

Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for imaging cancer-associated fibroblasts (CAFs) in the tumor microenvironment of a patient. The present teachings relate generally to method of making conjugates comprising a fibroblast activation protein (FAP) inhibitor.