Abstract: The disclosure relates to immunological compositions for vaccinating human beings against infection by the Human Immunodeficiency Virus (HIV).
Type:
Application
Filed:
January 26, 2012
Publication date:
April 3, 2014
Applicants:
SANOFI PASTEUR SA, POLYMUNE SCIENTIFIC IMMUNOBIOLOGISCHE FORSCHUNG GMBH, UNIVERSIDAD DE GRANADA, PX' THERAPEUTICS
Inventors:
Francisco Conejero-Lara, Irene Luque, Pedro Luis Mateo, Andreas Wagner, Raphaelle Claude, Marie-Gaelle Roger, Nicolas Mouz, Christophe Martin
Abstract: The present invention concerns a new method for the purification of Heparin Binding Hemagglutinin (HBHA) robust and reproducible at an industrial scale. The purification is made from HBHA-producing microorganisms extracted in presence of a detergent, a solvent or a chaotropic agent, followed by a first elution on ion exchange resins. In a preferred embodiment, the elution on ion exchange resins is followed by a second chromatography on mixed mode sorbents.
Type:
Application
Filed:
June 22, 2010
Publication date:
January 17, 2013
Applicant:
PX THERAPEUTICS
Inventors:
Aurelie Laronze, Nicolas Mouz, Joana Pech