Abstract: Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and stages R and I of acute kidney injury. Furthermore there are described peptides and test kits used in the invention. The described methods are intended to replace or complement the measurement of creatinine and/or cystatin C and/or NGAL for diagnosis of renal failure.
Type:
Application
Filed:
February 18, 2014
Publication date:
October 2, 2014
Applicant:
PXBiosciences LLC
Inventors:
Harald TAMMEN, Leif HONDA, Michael JURGENS, Andrew PECK
Abstract: Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and stages R and I of acute kidney injury. Furthermore there are described peptides and test kits used in the invention. The described methods are intended to replace or complement the measurement of creatinine and/or cystatin C and/or NGAL for diagnosis of renal failure.
Type:
Grant
Filed:
August 20, 2009
Date of Patent:
March 18, 2014
Assignee:
PxBioSciences LLC
Inventors:
Harald Tammen, Leif Honda, Michael Jurgens, Andrew Peck