Abstract: An intraosseous infusion device includes a base and an upper frame mounted to the base. An elongated needle is fixed to the upper frame. A fitting is provided for receiving liquid to be delivered to a patient's bone marrow and for supplying the liquid to a bore in the needle. The base includes a cam surface and the upper frame includes a cam follower. The cam surface is configured to cause the upper frame to rotate relative to the base as the needle moves longitudinally between a retracted position within the base and an extended position below the base.