Abstract: The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.
Type:
Application
Filed:
June 19, 2020
Publication date:
October 6, 2022
Applicant:
QBIOTICS PTY LTD
Inventors:
David William THOMAS, Paul Warren REDDELL, Glen Mathew BOYLE, Jason Kingsley CULLEN, Victoria Anne GORDON, Katja Etel HILL, Lydia Charlotte POWELL, Manon F. PRITCHARD, Peter G. PARSONS
Abstract: The present invention relates to methods of treating tumours comprising the localised administration, for example, intratumourally or topically, of an epoxytiglienone compound (as a monotherapy) to cancerous tumours to generate a systemic anticancer C abscopal (anenestic) and/or bystander effect.
Type:
Application
Filed:
April 9, 2020
Publication date:
June 23, 2022
Applicant:
QBIOTICS PTY LTD
Inventors:
Victoria Anne GORDON, Paul Warren REDDELL, Glen Mathew BOYLE, Jason Kingsley CULLEN, Peter Gordon PARSONS
Abstract: The present invention relates to a combination therapy for tumours comprising the administration of an epoxytigliane compound and an immune checkpoint inhibitor. In particular embodiments, there is a method of treating a tumour and/or treating or preventing one or more bystander tumours with the therapy. Pharmaceutical compositions and kits containing epoxytigliane compounds and immune checkpoint inhibitors are also described.
Type:
Grant
Filed:
March 23, 2018
Date of Patent:
January 4, 2022
Assignee:
QBIOTICS PTY LTD
Inventors:
Paul Warren Reddell, Jason Kingsley Cullen, Glen Mathew Boyle, Peter Gordon Parsons, Victoria Anne Gordon
Abstract: The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders.
Type:
Grant
Filed:
December 3, 2019
Date of Patent:
April 20, 2021
Assignee:
QBIOTICS PTY LTD
Inventors:
Paul Warren Reddell, Victoria Anne Gordon
Abstract: The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
Type:
Grant
Filed:
November 21, 2018
Date of Patent:
November 3, 2020
Assignee:
QBIOTICS PTY LTD
Inventors:
Paul Warren Reddell, Victoria Anne Gordon, Ryan Moseley, Robert Steadman, Rachael Louise Moses, Glen Mathew Boyle, Peter Gordon Parsons
Abstract: The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment.
Type:
Grant
Filed:
October 2, 2018
Date of Patent:
January 28, 2020
Assignee:
QBIOTICS PTY LTD
Inventors:
Paul Warren Reddell, Victoria Anne Gordon