Patents Assigned to Qiagen Gaithersburg
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Patent number: 9079183Abstract: Magnetic microplate assemblies are disclosed for assaying of biological activated magnetic particles from a supernatant. The assemblies include a magnetic microplate holder and a microplate including a plurality of wells for retaining the magnetic particles. The microplate holder includes a plurality of magnets for attracting the magnetic particles to the wells and a plurality of detents for securing the microplate in the holder. The detents allow the microplate to be tightly retained in the holder when the assembly is turned over to discard supernatant and wash buffer applied to rinse supernatant from the magnetic particles.Type: GrantFiled: March 15, 2013Date of Patent: July 14, 2015Assignee: QIAGEN GAITHERSBURG, INC.Inventors: Fei Yin, Bandele Jeffrey-Coker
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Patent number: 9051606Abstract: The present application relates to Multicomponent Nucleic Acid Enzymes (MNAzymes), which may be used for detecting, identifying and/or quantifying targets. More particularly, this application provides methods of designing and making more reliable MNAzymes, as well as compositions comprising MNAzyme components and methods of using MNAzymes.Type: GrantFiled: September 12, 2011Date of Patent: June 9, 2015Assignee: QIAGEN GAITHERSBURG, INC.Inventors: Guozhen Liu, Quan Peng, Yexun Wang, Samuel J. Rulli, Jing-Yi Lo, Rachel Gardner, Grace J. Kim
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Patent number: 8901287Abstract: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA:RNA hybrids which can be detected by a variety of methods.Type: GrantFiled: October 9, 2009Date of Patent: December 2, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Irina Nazarenko, Attila Lorincz, Paul Eder, Brian Lowe, Richard Mallonee, Ha Thai
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Patent number: 8877436Abstract: The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.Type: GrantFiled: October 26, 2009Date of Patent: November 4, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Paul Eder, Eric Payne, Irina Nazarenko, Suganthi Ramachandran, Arvind Virmani, Laura Bell
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Patent number: 8877507Abstract: An automated method for assuring sample adequacy. The method includes providing a sample in a testing container, activating an illumination source to pass an illumination beam through the testing container and into the sample, and detecting an intensity of an emitted beam. The emitted beam includes at least a portion of the illumination beam that has been scattered by the sample. The method also includes generating a sample turbidity measurement based on the intensity of the emitted beam, and determining, based on the sample turbidity measurement, an adequacy of the sample to provide accurate results in a primary test.Type: GrantFiled: October 9, 2009Date of Patent: November 4, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Jiulin Xia, Richard L. Mantefuel, Carl Theodore Edens, Jonathan Matthew Miller, Nadia P. Allen
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Publication number: 20140199686Abstract: The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: Shubing LIU, Suganthi RAMACHANDRAN
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Patent number: 8735564Abstract: The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.Type: GrantFiled: September 14, 2012Date of Patent: May 27, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Paul Eder, Eric Payne, Irina Nazarenko, Suganthi Ramachandran, Arvind Virmani, Laura Bell
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Patent number: 8722328Abstract: Methods and materials for improving nucleic acid or protein recovery from samples preserved in liquid cytological preservative solutions by utilizing scavenging agents, such as hydrazine- and hydrazide-containing compounds, are provided. Lysis solutions comprising hydrazine- and hydrazide-containing compounds and kits comprising the same are also provided.Type: GrantFiled: January 4, 2011Date of Patent: May 13, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Yuri Khripin, Arvind Virmani, Lori Kobayashi
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Publication number: 20140113277Abstract: An ultrasonic sample evaluation process in which a vial containing a liquid medium is placed on a receptacle and a ultrasonic source signal is propagated upwards in the vertical direction through the liquid medium. A number of reflected ultrasonic signals is received at the bottom of the sample vial and evaluated to identify a pattern characteristic of a reflection off the meniscus, and the presence of a pattern characteristic of a collection implement located in the liquid medium. An estimate of the amount of liquid medium contained in the sample vial is generated based on a time characteristic of the pattern characteristic of a reflection off the meniscus, and a signal indicating the presence of a collection implement in the liquid medium is generated upon identifying such a pattern.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventor: Bradley Scott Thomas
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Publication number: 20140113278Abstract: An automated process for converting samples includes: receiving tube strips having a number of sample tubes and samples therein, transferring multiple tube strips to a tube strip holder, dispensing sample conversion buffer into each tube, shaking the tube strip holder a first time, centrifuging the tube strip holder, removing a liquid supernatant from each tube, simultaneously inspecting the contents of each tube, dispensing a specimen transport medium and a denaturation reagent into each tube, shaking the tube strip holder a second time, heating the tube strip holder for a first length of time, shaking the tube strip holder a third time, heating the tube strip holder for a second length of time, shaking the tube strip holder a fourth time, and transferring at least a portion of each sample to a respective well on an output plate.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: BRADLEY SCOTT THOMAS, SUGANTHI RAMACHANDRAN, JASON TROXEL, BOWEN CUI, CARL THEODORE EDENS, ANDREW LEONARD, BERT JUNGHEIM
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Publication number: 20140112829Abstract: A tube strip handling and heating frame having a rectangular outer frame having two spaced longitudinal walls extending in a longitudinal direction, and two spaced lateral walls extending in a lateral direction and extending between respective ends of the longitudinal walls. The outer frame forms an enclosure having an open upper side and an open lower side. The frame also has a number of tube strip wells located inside the outer frame, each tube strip well has a slot elongated in the lateral direction, and each slot is configured to receive a respective tube strip through the open upper side and support the respective tube strip in a vertical direction. The tube strip wells are arranged in a series along the longitudinal direction.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: BRADLEY SCOTT THOMAS, Carl Theodore Edens, Andrew Leonard, Bert Jungheim, Peter Haviernik, Bowen Cui
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Publication number: 20140112558Abstract: A method for visually inspecting pelletized samples. The method generates an inspection image of the bottom of a sample tube holder. The sample tube holder has a number of sample tube locations, and each sample tube location is configured to receive a sample tube in it. The inspection image is evaluated to determine whether a tube image exists for each sample tube location, and each sample tube image is evaluated to determine whether a pellet is located in each sample tube.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: BRIAN BEAN, STEVE MARLOW, BRADLEY SCOTT THOMAS
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Publication number: 20140112842Abstract: An automated sample tube blotting system having one or more rotating grippers, a supply of absorbent material, a transporter, and an absorbent material removal mechanism. Each rotating gripper has a respective holder configured to selectively mate with a respective interface on a tube strip, and the one or more rotating grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the rotating gripper in a lateral direction from a starting location to a location above the absorbent material, and in a vertical direction towards and away from the absorbent material.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: Bradley Scott Thomas, Brian Austin Self, Eric Schneider, Franklin Regan
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Publication number: 20140112843Abstract: An automated sample tube decanting system having one or more decanting grippers, a decant waste receptacle, a transporter, and means for rotating the decanting gripper. Each decanting gripper has a respective holder configured to selectively mate with a respective interface on a tube strip. The one or more decanting grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the one or more decanting grippers in a lateral direction from a starting location to a location above the decant waste receptacle.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: Bradley Scott Thomas, Brian Austin Self, Andrew Leonard, Bert Jungheim, Eric Schneider, Franklin Regan, Bowen Cui, Shubing Liu
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Publication number: 20140112845Abstract: A cover for covering an array of sample tubes during an incubation process. The cover has an upper panel and protrusions extending downward from the upper panel. Each protrusion has an upper seal and a lower seal. The upper seal includes a first conical section that tapers from a first diameter that is larger than the inside diameter of a corresponding sample tube to a second diameter that is smaller than the inside diameter of the corresponding sample tube. The lower seal includes a cylindrical section extending downward from the bottom of the first conical section. The cylindrical section has a diameter selected to create a capillary seal, in the presence of a liquid, between the cylindrical section and an adjacent portion of an inner wall of the corresponding sample tube.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicant: QIAGEN GAITHERSBURG, INC.Inventors: CARL THEODORE EDENS, ANDREW LEONARD, BERT JUNGHEIM, PETER HAVIERNIK, BOWEN CUI
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Patent number: 8703492Abstract: An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container.Type: GrantFiled: October 9, 2009Date of Patent: April 22, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Brian Austin Self, Jonathan Matthew Miller, Carl Theodore Edens
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Patent number: 8658417Abstract: The present disclosure provides an automated sample processing system that can receive samples in different first and second formats and process both sample formats. The disclosure also provides a human papillomavirus testing apparatus. The apparatus has a first input to receive first test specimens in the form of pre-processed cervical samples, and a second input to receive unprocessed cervical samples. A first subsystem prepares second test specimens from the unprocessed cervical samples, and a second subsystem selectively processes and tests first specimens, second test specimens, or first and second test specimens to determine the presence of one or more human papillomavirus indicators.Type: GrantFiled: July 6, 2010Date of Patent: February 25, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: James Hal Godsey, Emmett Brown, Jay Srinivasan, Bandele Jeffrey-Coker, Jon Willoughby
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Patent number: 8647593Abstract: Magnetic microplate assemblies are disclosed for assaying of biological activated magnetic particles from a supernatant. The assemblies include a magnetic microplate holder and a microplate including a plurality of wells for retaining the magnetic particles. The microplate holder includes a plurality of magnets for attracting the magnetic particles to the wells and a plurality of detents for securing the microplate in the holder. The detents allow the microplate to be tightly retained in the holder when the assembly is turned over to discard supernatant and wash buffer applied to rinse supernatant from the magnetic particles.Type: GrantFiled: June 8, 2009Date of Patent: February 11, 2014Assignee: Qiagen Gaithersburg, Inc.Inventors: Fei Yin, Bandele Jeffrey-Coker
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Patent number: 8628914Abstract: Disclosed herein are methods and kits relating to detection and quantitation of helicase activity.Type: GrantFiled: May 26, 2011Date of Patent: January 14, 2014Assignee: QIAGEN Gaithersburg, Inc.Inventors: Nadia Allen, Peter Qiu
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Publication number: 20130315800Abstract: Magnetic microplate assemblies are disclosed for assaying of biological activated magnetic particles from a supernatant. The assemblies include a magnetic microplate holder and a microplate including a plurality of wells for retaining the magnetic particles. The microplate holder includes a plurality of magnets for attracting the magnetic particles to the wells and a plurality of detents for securing the microplate in the holder. The detents allow the microplate to be tightly retained in the holder when the assembly is turned over to discard supernatant and wash buffer applied to rinse supernatant from the magnetic particles.Type: ApplicationFiled: March 15, 2013Publication date: November 28, 2013Applicant: QIAGEN GAITHERSBURG, INC.Inventors: Fei YIN, Bandele JEFFREY-COKER