Patents Assigned to QINGDAO HARWARS BIOLOGY GROUP LTD.
  • Patent number: 11484588
    Abstract: A paramyxovirus vaccine strain for novel coronavirus pneumonia and a construction method thereof are provided. The method includes performing a recombination of N and F genes of Newcastle disease virus type VII of Paramyxoviridae with P, M, H, L genes of Canine distemper virus of Paramyxoviridae to obtain a recombinant virus, inserting S1 gene of the novel coronavirus between the P and M genes of the recombinant virus to obtain a recombinant vector. The vaccine strain constructed can stably and efficiently express the novel coronavirus S1 protein, and induce the body to produce antibodies; and the recombined virus vaccine strain can stimulate the human body to produce mucosal immunity, and the prepared vaccine can be vaccinated through a nasal spray. Moreover, the vaccine strain can be tested in poultry and dogs, saving time, reducing costs, and being more conducive to actual production due to large output.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: November 1, 2022
    Assignee: QINGDAO HARWARS BIOLOGY GROUP LTD.
    Inventors: Mingyi Li, Gang Liu, Chunlin Yi, Fenglong Ma, Zongke Wang, Yujie Xia, Xiaochen Cui, Zhen Yang, Hongshang Chang, Bingbing Zhao, Jie Yang