Abstract: A method of manufacturing a puncture resistant leakless material for tubeless tires, the puncture resistant leakless material manufactured thereof, and a method of spray coating the puncture resistant leakless material to tires are described. Thermoplastic elastomers are used as the framework material for the puncture resistant leakless material. The puncture resistant leakless material resists high temperature, low temperature, oil, and water, has high leakproof properties, and has low manufacturing costs. The puncture resistant leakless material also has a high tear resistance, a great resilience, and a long service life. The raw materials for manufacturing the puncture resistant leakless material fir tubeless tire do not need to undergo vulcanization, resulting in reduced energy consumption and lowered manufacturing costs.