Patents Assigned to Qool Therapeutics, Inc.
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Publication number: 20210346191Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O2 or SF/O2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.Type: ApplicationFiled: December 23, 2020Publication date: November 11, 2021Applicant: Qool Therapeutics, Inc.Inventor: Amir Belson
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Patent number: 11020269Abstract: A treatment system delivers a breathing gas and frozen ice or other particles (FSP) to a bronchus of a lung of a patient in order to induce hypothermia. The breathing gas and the FSP are usually delivered through separate lumens. Clogging of an FSP lumen can be inhibited by heating and/or cooling of the lumen. The temperature of exhaled gases or a body temperature may be measured, and a controller can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured temperature.Type: GrantFiled: February 23, 2016Date of Patent: June 1, 2021Assignee: Qool Therapeutics, Inc.Inventors: Michael S. Mirizzi, Pankaj Rathi, Edward J. Hayes, Amir Belson, Jeff Glen Haydon
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Publication number: 20210137731Abstract: A treatment system delivers a breathing gas and frozen ice or other particles (FSP) to a bronchus of a lung of a patient in order to induce hypothermia. The breathing gas and the FSP are usually delivered through separate lumens. Clogging of an FSP lumen can be inhibited by heating and/or cooling of the lumen. The temperature of exhaled gases or a body temperature may be measured, and a controller can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured temperature.Type: ApplicationFiled: January 15, 2021Publication date: May 13, 2021Applicant: Qool Therapeutics, Inc.Inventors: Michael S. Mirizzi, Pankaj Rathi, Edward J. Hayes, Amir Belson, Jeff Glen Haydon
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Patent number: 10893976Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O2 or SF/O2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.Type: GrantFiled: May 31, 2017Date of Patent: January 19, 2021Assignee: Qool Therapeutics, Inc.Inventor: Amir Belson
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Publication number: 20200238039Abstract: A therapeutic treatment system has a delivery device is adapted to deliver a cooled breathing gas mixture to a patient and an injection device positioned near a distal end of the delivery device. The injection device is coupled to a source of liquid. The treatment system also includes a control system coupled to the delivery device and the injection device. Alternatively, the control system is adapted to control the injection device to release a fluid into the cooled breathing gas mixture to form a frozen mist of fine ice particles in the cooled breathing gas mixture.Type: ApplicationFiled: September 3, 2019Publication date: July 30, 2020Applicant: Qool Therapeutics, Inc.Inventors: Amir Belson, Robert M. Ohline, Nimrod Tzori
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Publication number: 20200129716Abstract: Apparatus for transporting particles through a patient's trachea into the respiratory system include a delivery tube having at least a ventilation lumen and a particle delivery lumen. The delivery tube has a centering device near its distal tip, such as a balloon eccentrically mounted on the tube to position an outlet of the particle delivery lumen near a centerline of the trachea above the carina branching into the right and left bronchus. A proximal end of the delivery tube connects to a source of particles, and a controller may be provided to adjust a rate and/or an amount of the particles delivered to the patient. In a specific example, frozen particles are delivered to control core body temperature. In other instances, the particle may be a medicament or other substance for effecting other therapies or diagnostic procedures.Type: ApplicationFiled: October 29, 2019Publication date: April 30, 2020Applicant: Qool Therapeutics, Inc.Inventor: Michael J. Horzewski
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Publication number: 20200038237Abstract: Peritoneal heat exchange provides the benefit of extremely rapid cooling of the patient's target organs such as the heart and brain as well as facilitating global patient body temperature reduction to therapeutically effective temperatures. The heat exchange medium of the present invention is a chilled gaseous fluid suspension of frozen ice particles.Type: ApplicationFiled: February 12, 2019Publication date: February 6, 2020Applicant: Qool Therapeutics, Inc.Inventor: Amir Belson
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Publication number: 20190290482Abstract: Systems for dense phase transport of frozen and other particles to the respiratory system include a particle source, a delivery chamber for metering boluses of the particles from the source, and a transfer tube for fluidized transport of the particles to a patient interface. A controller may be provided to adjust the rate and amount of the bolus deliver to a patient to control core body temperature and for other purposes.Type: ApplicationFiled: June 10, 2019Publication date: September 26, 2019Applicant: Qool Therapeutics, Inc.Inventors: Jeff G. Haydon, Edward J. Hayes, III
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Patent number: 10238831Abstract: A treatment system includes a delivery device which delivers a combination of a breathing gas and frozen ice or other particles to a patient in order to induce hypothermia. The treatment system also includes a temperature system for measuring the temperature of exhaled gases and a controller which can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured exhalation gas temperature.Type: GrantFiled: September 5, 2014Date of Patent: March 26, 2019Assignee: Qool Therapeutics, Inc.Inventor: Amir Belson
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Patent number: 10238533Abstract: Peritoneal heat exchange provides the benefit of extremely rapid cooling of the patient's target organs such as the heart and brain as well as facilitating global patient body temperature reduction to therapeutically effective temperatures. The heat exchange medium of the present invention is a chilled gaseous fluid suspension of frozen ice particles.Type: GrantFiled: July 15, 2016Date of Patent: March 26, 2019Assignee: Qool Therapeutics, Inc.Inventor: Amir Belson
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Publication number: 20180325817Abstract: A treatment system delivers a breathing gas and frozen stem cells or other biologic particles (FBP) to a bronchus of a lung of a patient in order to treat lung and other conditions. The breathing gas and the FBP are usually delivered through separate lumens. The FBP may be delivered concurrently with other frozen particles, such as frozen saline particles (FSP). The FBP/FSP will remain frozen at all times from preparation to delivery, and will thaw only after they are released into the lung.Type: ApplicationFiled: July 25, 2018Publication date: November 15, 2018Applicant: Qool Therapeutics, Inc.Inventors: Andriy Batchinsky, Ben Antebi, Brendan M. Beely, Leopoldo C. Cancio, Amir Belson, Beverly Huss, Edward J. Hayes, Jeff G. Haydon
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Publication number: 20180153739Abstract: A treatment system delivers a breathing gas and frozen ice or other particles (FSP) to a bronchus of a lung of a patient in order to induce hypothermia. The breathing gas and the FSP are usually delivered through separate lumens. Clogging of an FSP lumen can be inhibited by heating and/or cooling of the lumen. The temperature of exhaled gases or a body temperature may be measured, and a controller can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured temperature.Type: ApplicationFiled: February 23, 2016Publication date: June 7, 2018Applicant: Qool Therapeutics, Inc.Inventors: Michael S. Mirizzi, Pankaj Rathi, Edward J. Hayes, Amir Belson, Jeff Glen Haydon
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Publication number: 20170266037Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O2 or SF/O2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.Type: ApplicationFiled: May 31, 2017Publication date: September 21, 2017Applicant: Qool Therapeutics, Inc.Inventor: Amir Belson
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Patent number: 9757272Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O2 or SF/O2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.Type: GrantFiled: March 13, 2015Date of Patent: September 12, 2017Assignee: Qool Therapeutics, Inc.Inventor: Amir Belson
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Patent number: 9414959Abstract: Peritoneal heat exchange provides the benefit of extremely rapid cooling of the patient's target organs such as the heart and brain as well as facilitating global patient body temperature reduction to therapeutically effective temperatures. The heat exchange medium of the present invention is a chilled gaseous fluid suspension of frozen ice particles.Type: GrantFiled: September 5, 2012Date of Patent: August 16, 2016Assignee: Qool Therapeutics, Inc.Inventor: Amir Belson
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Patent number: 9004066Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O2 or SF/O2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.Type: GrantFiled: February 28, 2013Date of Patent: April 14, 2015Assignee: Qool Therapeutics, Inc.Inventor: Amir Belson
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Publication number: 20150068525Abstract: A treatment system includes a delivery device which delivers a combination of a breathing gas and frozen ice or other particles to a patient in order to induce hypothermia. The treatment system also includes a temperature system for measuring the temperature of exhaled gases and a controller which can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured exhalation gas temperature.Type: ApplicationFiled: September 5, 2014Publication date: March 12, 2015Applicant: Qool Therapeutics, Inc.Inventor: Amir Belson