Abstract: The invention features a substrate and compositions, kits, devices, and methods employing the substrate that produces an isolated population of cells from a general population. The isolated population is enriched for one or more target populations. Substrate is can be liquefied and allows recovery of unlabeled, viable, and functional cells.
Type:
Grant
Filed:
March 20, 2017
Date of Patent:
January 31, 2023
Assignee:
QT Holdings Corp
Inventors:
Sean H. Kevlahan, Andrew Ball, Guokui Qin, Steven B. Wells
Abstract: The invention features shaped articles containing a structure and a hydrogel coating thereon, the hydrogel coating containing alginic acid conjugated to a polyalkylene oxide and a binding moiety. The hydrogel coating on the structure is sized and shaped to fit in a well in a microtiter plate and the coating does not cover the entire exterior of the surface. The invention further features methods of capturing targets using shaped articles and methods of preparing shaped articles.
Type:
Grant
Filed:
March 24, 2015
Date of Patent:
August 11, 2020
Assignee:
QT Holdings Corp
Inventors:
Sean H. Kevlahan, Brian D. Plouffe, Jeffrey A. Zonderman
Abstract: The invention features a complex that binds to, stimulates, and expands a desired T cell population and facilitates separation of the target population from a sample. The complex can be gently dissociated from the binding unit after separating the desired T cell population, representing a safe and efficient approach for processing T cells for clinical use. Invention also provides methods of using such complexes as part of adoptive T cell therapy systems.
Type:
Grant
Filed:
August 4, 2016
Date of Patent:
October 17, 2017
Assignee:
QT Holdings Corp
Inventors:
Sean H. Kevlahan, Andrew Ball, Guokui Qin, Steven B. Wells, Nithya Jothi Jesuraj
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