Patents Assigned to Quadrant Holdings Cambridge Ltd.
  • Dry powder compositions
    Patent number: 6551622
    Abstract: A hydrophilic therapeutic agent is prepared in storage-stable form, suitable for administration to a patient. The agent is formulated with a hydrophobically-derivatized carbohydrate, making use of ion-pair formation to form a solution of the agent and carbohydrate.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: April 22, 2003
    Assignee: Quadrant Holdings Cambridge, Ltd
    Inventor: Peter Jackson
  • Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
    Patent number: 6517860
    Abstract: The invention encompasses compositions for increased bioavailability through mucosal delivery comprising, preferably in powder form, an intimate mixture of an effective amount of a bioactive agent and a hydrophobically derivatized carbohydrate. The compositions can also contain a surface active agent preferably for delivery to gastrointestinal mucosa and ocular delivery.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: February 11, 2003
    Assignee: Quadrant Holdings Cambridge, Ltd.
    Inventors: Bruce J. Roser, Ian Sanderson, Jaap Kampinga, Camilo Colaco
  • Methods for producing dried storage-stable platelets and compositions obtained thereby
    Patent number: 6221575
    Abstract: The invention provides methods for drying platelets to obtain compositions which are storage stable over a wide range of temperatures and for an extended period of time. The invention also provides compositions obtained thereby and devices for use therein.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: April 24, 2001
    Assignee: Quadrant Holdings Cambridge Ltd.
    Inventors: Bruce J. Roser, Valentine Menys, Lynda Grandage, Diana Phipps
  • Tablet dosage form of clavulanic acid and amoxycillin comprising a trehalose excipient
    Patent number: 6194001
    Abstract: Provided are tablet formulations in one embodiment comprising clavulanic acid or salt thereof, amoxycillin, and trehalose. The trehalose is, for example, amorphous anhydrous trehalose. The amorphous anhydrous trehalose is present in an amount, for example, of 5 to 50%. The formulation may further comprise, for example, desiccants, such as silica gel, or lubricants.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: February 27, 2001
    Assignee: Quadrant Holdings Cambridge Ltd.
    Inventors: Enda Martin Gribbon, Glen Patrick Martyn, Camilo Anthony Leo Selwyn Colaco
  • Oral solid dosage forms, methods of making same and compositions thereof
    Patent number: 5958455
    Abstract: Methods of making tablets of a variety of physical forms are described. The tablets can be made into a wide variety of formulations. The invention further provides methods of making crystalline and amorphous anhydrous trehalose for use in formulating tablets suitable for use in dispensing pharmaceutical agents.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: September 28, 1999
    Assignee: Quadrant Holdings Cambridge Ltd
    Inventors: Bruce J. Roser, Julian Blair, Camilo Colaco, Ross Henry Morris Hatley
  • Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
    Patent number: 5762961
    Abstract: The invention provides methods of making rapidly soluble tablets of decreased weight compared to similar solid tablets. The invention further provides novel, rapidly soluble tablets of decreased weight compared to similar solid tablets. The tablets offer increased rates of dissolution and disintegration.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: June 9, 1998
    Assignee: Quadrant Holdings Cambridge Ltd.
    Inventors: Bruce J. Roser, Julian Blair