Abstract: The present invention relates to compositions and methods for enhancement of sexual pleasure and disorders related to sexual pleasure especially in mammalian females. The present invention relates to all aspects of modulating the female sexual response, including female sexual dysfunction such as female sexual arousal disorders (FSAD), orgasmic disorders, sexual pain disorders and enhancing female sexual pleasure and satisfaction. The present invention relates to compositions comprising botanical extracts and active agents which are useful to treat or affect any of the aforementioned conditions. The present invention relates to a composition, preferably for topical or local use, which comprises one or more of the following ingredients; including, but not limited to, borage seed oil, Angelica pubescens root and other Angelica species, Coleus forskohlii extract, vinpocetine, ferulic acid, magnesium, ascorbyl palmitate, capric triglyceride, caprylic triglyceride, silica and equivalents thereof.