Abstract: Briefly described, embodiments of the present invention pertains to a key performance indicator (KPI)-driven digital genome system or framework as well as various systems and methods of use and interaction therewith. Unlike conventional stand-alone KPI applications or pure-play centralized KPI solutions, embodiments of the present invention provide an automated way to codify the organizational objectives, goals, behavior, and motivations by continuously measuring, correlating, and discovering hidden relationships among various metrics, attributes, causal relationships, and networks display genomic findings via business applications without a priori knowledge of machine learning or statistical techniques.