Abstract: An apparatus for treating solid tumors having at least one hollow needle having at least one perforation, at least one ground electrode, a pump for delivering a chemotherapeutic agent through the perforation in the hollow needle, one or more power supplies connected to the hollow needle and the ground electrode capable of delivering a pulse of alternating current between the hollow needle and the ground electrode of at least 1000 volts and no more than 1 millisecond duration, a direct current between the hollow needle and the ground electrode between about 1 mA and 100 mA, and a second alternating current having a frequency range between about 1 MHz and 1000 MHz.

Abstract: An apparatus for treating solid tumors having at least one hollow needle having at least one perforation, at least one ground electrode, a pump for delivering a chemotherapeutic agent through the perforation in the hollow needle, one or more power supplies connected to the hollow needle and the ground electrode capable of delivering a pulse of alternating current between the hollow needle and the ground electrode of at least 1000 volts and no more than 1 millisecond duration, a direct current between the hollow needle and the ground electrode between about 1 mA and 100 mA, and a second alternating current having a frequency range between about 1 MHz and 1000 MHz.