Abstract: Systems and methods are disclosed in which a diagnostic probe is configured for performing diagnostic measurements and/or therapeutic interventions and for measuring the local surface profile of a local surface region an object. Various example embodiments are described in which the surface profile of the local surface region, when compared to the surface profile of an extended surface region, is employed to provide guidance for positioning and/or orienting the probe when performing a diagnostic measurement. The surface profile within the local surface region may be employed to generate feedback for repeating a previous diagnostic measurement, such that the repeat measurement is performed at the previous location on the object. In other embodiments, surface profile detection is employed to control the positional and/or orientational probe alignment during an iterative tissue removal method in which successive tissue layers are removed when the presence of a pathology is confirmed via a diagnostic measurement.

Abstract: An apparatus is provided for performing photothermal measurements on a object. The apparatus, which may be provided as a handpiece, houses optical components including a laser, an infrared detector, a dichroic beamsplitter, and focusing and beam directing optics for the delivery of a laser beam to, and the collection of photothermal radiation from, a measured object. Some of the optical components may be provided on an optical bench that is directly attached to a thermally conductive tip portion for the passive heat sinking of internal optical components. The apparatus may further include a sampling optical element and a photodetector for the detection of luminescence, and a camera for obtaining an image of the object during a diagnostic procedure. The apparatus may be employed for the scanning of a tooth to determine an oral health status of the tooth.

Abstract: A detection system is provided for the measurement of in-vitro dental samples. The detection system includes an optical detection module that is configured for the detection of optical signals that are emitted in response to the absorption of an incident optical beam, and a control and processing unit that is configured for processing the detected optical signals and generating an image. The system also includes a sample holder may be removed and subsequently replaced without requiring recalibration of the system. In some embodiments, the optical detection module is configured for combined measurement of photothermal radiation and luminescence in response to the absorption of the incident optical beam.

Abstract: A detection system is provided for the measurement of in-vitro dental samples. The detection system includes an optical detection module that is configured for the detection of optical signals that are emitted in response to the absorption of an incident optical beam, and a control and processing unit that is configured for processing the detected optical signals and generating an image. The system also includes a sample holder may be removed and subsequently replaced without requiring recalibration of the system. In some embodiments, the optical detection module is configured for combined measurement of photothermal radiation and luminescence in response to the absorption of the incident optical beam.

Abstract: An apparatus is provided for performing photothermal measurements on a object. The apparatus, which may be provided as a handpiece, houses optical components including a laser, an infrared detector, a dichroic beamsplitter, and focusing and beam directing optics for the delivery of a laser beam to, and the collection of photothermal radiation from, a measured object. Some of the optical components may be provided on an optical bench that is directly attached to a thermally conductive tip portion for the passive heat sinking of internal optical components. The apparatus may further include a sampling optical element and a photodetector for the detection of luminescence, and a camera for obtaining an image of the object during a diagnostic procedure. The apparatus may be employed for the scanning of a tooth to determine an oral health status of the tooth.

Abstract: A method is provided for analyzing and displaying an oral health status of a tooth or an entire dentition based on a measurement with a diagnostic device. Diagnostic data pertaining to a selected tooth, tooth surface, section of tooth surface or numbers of teeth in a mouth is recorded from an oral health diagnostic device, optionally along with an image of the particular tooth or tooth surface examined. The diagnostic data is processed and compared with reference data to determine an oral health status of the tooth. The oral health status of the tooth is then displayed on an odontogram shown in a user interface. The user interface may also provide reports comparing changes in the measured data and/or images along with the therapies used, thereby enabling the measurement and tracking of outcomes from various therapies over time.

Abstract: A method of oral health risk assessment is provided in which diagnostic data from an oral health detection device and patient risk factor data is processed to provide a integrated risk measure relating to a patient's dental health. The patient risk factor data preferably includes risk factor data such as pathological risk factors, protective risk factors, historical factors, self care factors, behavioral factors, and extrinsic factors. The integrated risk assessment and patient data is preferably provided to a remote server for access by various authorized stakeholders.

Abstract: There is provided a high-spatial-resolution dynamic diagnostic instrument which can provide simultaneous measurements of laser-induced frequency-domain infrared photothermal radiometric and alternating-current (ac) modulated luminescence signals from defects, demineralization, remineralization and caries in teeth intraorally. The emphasis is on the abilities of this instrument to approach important problems such as the detection, diagnosis and ongoing monitoring of carious lesions and or defects on the occlusal pits and fissures, smooth surfaces and interproximal areas between teeth which normally go undetected by x-ray radiographs or visual examination. The instrument is also able to detect early areas of demineralized tooth and or areas of remineralized tooth as well as defects along the margins of restorations. This capability of inspecting a local spot can be extended to a modulated imaging of sub-surface of target tooth by using a multi-array infrared camera.

Abstract: A method of oral health risk assessment is provided in which diagnostic data from an oral health detection device and patient risk factor data is processed to provide a integrated risk measure relating to a patient's dental health. The patient risk factor data preferably includes risk factor data such as pathological risk factors, protective risk factors, historical factors, self care factors, behavioral factors, and extrinsic factors. The integrated risk assessment and patient data is preferably provided to a remote server for access by various authorized stakeholders.